(MENAFN- GlobeNewsWire - Nasdaq) CD39-Targeted Therapies Near Key Milestones, First Approval Projected by 2029

Dublin, Jan. 28, 2025 (GLOBE NEWSWIRE) -- The "CD39 Targeted Therapies Clinical Trials, Therapeutic Approaches & Market Opportunity Insight 2025" report has been added to ResearchAndMarkets.com's offering.

CD39 targeting therapies are emerging as a promising strategy for modulating immune responses in a range of diseases. CD39 serves as a vital ectonucleotidase that influences the purinergic signaling pathway, thereby regulating the equilibrium between immune activation and suppression.

By converting ATP into AMP, which is further transformed into adenosine by CD73, CD39 is instrumental in establishing an immunosuppressive microenvironment. This environment is particularly advantageous for tumors but also plays a role in chronic infections and autoimmune diseases. Inhibiting CD39 activity may restore immune functionality and enhance patient outcomes in these contexts.

Report Highlights:

• First CD39 Targeted Therapy Approval Expected By 2029
• CD39 Targeted Therapies In Clinical Trials: > 15 Therapies
• CD39 Inhibitors Clinical Trials Insight By Company, Country, Indication and Phase
• CD39 Targeted Therapy Research and Development Trends By Indication
• CD39 Targeted Therapies Proprietary Technologies Platforms By Company

In the realm of oncology, the contribution of CD39 to immune suppression within the tumor microenvironment (TME) is well-established. Tumors frequently utilize the CD39-CD73-adenosine axis to evade immune surveillance, resulting in immune cell exhaustion and diminished anti-tumor responses. Elevated levels of CD39 on regulatory T cells (Tregs) and CD8+ T cells have been associated with unfavorable prognoses in various malignancies. By employing monoclonal antibodies that target CD39, such as IPH5201, it is possible to reactivate the immune system to more effectively combat tumor cells. IPH5201, which is being developed by Innate Pharma and AstraZeneca, is currently under investigation in conjunction with immune checkpoint inhibitors (ICIs) to enhance the immune response in patients with solid tumors.

In addition to cancer, CD39-targeting therapies show considerable potential for addressing other diseases, particularly chronic viral infections, autoimmune disorders, and sepsis. In the context of chronic infections like HIV, tuberculosis, and Chagas disease, CD39 is implicated in immune exhaustion and suppression, which obstructs effective immune responses. By inhibiting CD39, there is a possibility of reversing immune dysfunction and improving the body's capacity to eliminate pathogens. In autoimmune disorders, where there is an overactivation of the immune system, the targeting of CD39 may aid in reestablishing equilibrium by enhancing the inhibitory function of regulatory T cells, which are vital for averting tissue damage.

The therapeutic promise of targeting CD39 also encompasses sepsis, as CD39 expression on monocytes and macrophages is instrumental in regulating inflammation. In the context of sepsis, achieving a balanced immune response is crucial to mitigate tissue injury while effectively managing infection. By inhibiting the activity of CD39, therapeutic interventions could diminish excessive inflammation and restore immune homeostasis, presenting a novel strategy for addressing this critical condition.

The clinical advancement of therapies aimed at CD39 is still in its nascent phase, with several candidates progressing through clinical trials, particularly in Phase 2. Among these, IPH5201 stands out as a leading candidate, demonstrating encouraging outcomes in both preclinical and early-phase clinical investigations. These antibodies are being assessed not only in oncology but also across a range of chronic conditions where CD39 plays a significant role in immune regulation. By focusing on CD39, these therapies seek to bolster immune responses in scenarios characterized by immune suppression or dysfunction.

Looking forward, the potential uses of CD39-targeting therapies are extensive. The integration of anti-CD39 antibodies with other treatment modalities, such as immune checkpoint inhibitors or antiviral therapies, presents the opportunity for synergistic effects, thereby enhancing the immune response. Nonetheless, challenges persist, particularly concerning the context-dependent function of CD39 across various diseases and patient demographics.

Achieving a precise balance between immune activation and suppression will be essential for the safe and effective implementation of these therapies. As clinical trials advance and additional data is collected, therapies targeting CD39 may emerge as a fundamental component of personalized medicine, effectively addressing various diseases through the precise and controlled modulation of immune responses.

Key Topics Covered:

Introduction To CD39 Targeting Therapies

• Role of CD39 & Emergence As Therapeutic Target
• Discovery of CD39 & Development Of Targeting Therapies

CD39 Targeting Therapies Mechanism Of Action

• CD39 Inhibition
• CD39 Agonism

Current CD39 Targeting Therapy Approaches

• Antibodies
• Nucleic Acid Therapeutics
• Small Molecule Inhibitors

Global CD39 Targeted Therapies Clinical Trials Overview

• By Company
• By Indication
• By Country
• By Phase

CD39 Targeted Therapies Clinical Trials Insight By Company, Country, Indication & Phase

• Research
• Preclinical
• Phase I
• Phase II

Global CD39 Targeting Therapy Market Trends & Developments

• Current Market Outline
• Future Market Opportunities

Role Of CD39 Targeting Therapies By Indication: Clinical Development & Collaborations

• Cancer
• Autoimmune & Inflammatory Diseases
• Cardiovascular Diseases
• Infections

CD39 Targeted Therapies Technology Platforms

• OligoCreator & LNAplus Platforms - Secarna Pharmaceuticals
• Unnamed Platforms - Biotheus
• Unnamed Platform - Adimab
• OriAb Antibody Discovery Platform - Oricell Therapeutics
• TMAb Platform - Sensei Biotherapeutics

Global CD39 Targeted Therapies Market Dynamics

• Market Drivers & Opportunities
• Market Challenges & Restraints

Competitive Landscape

• Adimab
• Arcus Biosciences
• Biotheus
• BrightPath Biotherapeutics
• Elpiscience Biopharmaceuticals
• Innate Pharma
• Orega Biotech
• OriCell Therapeutics
• Secarna Pharmaceuticals
• Trishula Therapeutics

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