Severe Asthma Clinical Trial Pipeline Appears Robust With 40+ Key Pharma Companies Actively Working In The Therapeutics Segment Delveinsight

(MENAFN- PR Newswire)

The severe asthma market is fueled by the rising prevalence of the condition, particularly in urban areas, alongside the emergence of innovative therapies like biologics targeting IgE and cytokine modulators. A growing demand for personalized medicine enhances treatment efficacy and patient compliance. Government initiatives and increased awareness improve access to care, while advancements in inhaler technology boost medication adherence. Collaborative efforts in R&D are also vital for driving innovation in asthma treatments.

LAS VEGAS, Nov. 6, 2024 /PRNewswire/ -- DelveInsight's
' Severe Asthma Pipeline Insight 2024 '
report provides comprehensive global coverage of pipeline severe asthma therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the severe asthma pipeline domain.

Key Takeaways from the Severe Asthma Pipeline Report

• DelveInsight's severe asthma pipeline report depicts a robust space with 40+ active players working to develop 50+ pipeline therapies for severe asthma treatment.
  
• Key severe asthma companies such as Kinaset Therapeutics, Bio-Thera Solutions, CSPC ZhongQi Pharmaceutical Technology, AB Science, GlaxoSmithKline, Oneness Biotech, Biosion, Lanier Biotherapeutics, Kymera Therapeutics, Suzhou Connect Biopharmaceuticals, Upstream Bio, Teva Branded Pharmaceutical Industries, Sanofi, Jiangsu Hengrui Medicine, AstraZeneca, Advagene Biopharma, Genrix (Shanghai) Biopharmaceuticals, and others are evaluating new severe asthma drugs to improve the
  treatment landscape.
• Promising severe asthma pipeline therapies such as KN-002, BAT2606, CM326, Masitinib, GSK3511294, FB 704A, BSI-045B, LNR 125.38, KT 621, CBP-201, Verekitug, TEV'248, Rilzabrutinib, SHR-1905, Atuliflapon, AD17002, GR1802, and others are under different phases of severe asthma clinical trials.
• In September 2024, Kinaset Therapeutics announced two oral presentations and a late-breaking poster presentation at the 2024 European Respiratory Society (ERS) Congress . The presentations demonstrate the potential of Kinaset's lead clinical candidate, frevecitinib ( KN-002 ), to treat all patients with moderate to severe asthma and patients with COPD.
• In May 2024, GSK
  announced positive headline results from the phase III clinical trials SWIFT-1 and SWIFT-2, which assessed the efficacy and safety of depemokimab versus placebo in adults and adolescents with severe asthma with type 2 inflammation characterized by blood eosinophil count.
  
• In April 2024,
  Twenty-five abstracts across approved and investigational medicines will be presented at this year's American Thoracic Society (ATS) International Conference. Notable data presentations for Sanofi's immunology pipeline include the first presentation of phase IIb moderate to severe asthma data for rilzabrutinib .
• In October 2023,
  Upstream Bio
  announced positive interim results in its Phase Ib clinical study of UPB-101, a thymic stromal lymphopoietin receptor (TSLPR) inhibitor. The Phase Ib study is a randomized, double-blinded, placebo-controlled multiple ascending dose (MAD) study with subcutaneous (SC) administration conducted in asthma patients.
  
• In October 2023,
  Aiolos Bio with an asthma drug in clinical trials, announced that it raised $245 million in Series A funding. Atlas Venture, Bain Capital Life Sciences, Forbion Capital Partners and Sofinnova Investments led the round, with additional investment from RA Capital Management

Request a sample and discover the recent advances in severe asthma treatment drugs @ Severe Asthma Pipeline Report

The severe asthma pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage severe asthma drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the severe asthma clinical trial landscape.

Severe Asthma Overview

Severe asthma is a chronic respiratory condition characterized by persistent symptoms that are difficult to control, even with high-dose medications. Unlike milder forms of asthma, severe asthma can significantly impair the quality of life and may result in frequent exacerbations requiring hospitalization.

The exact cause of severe asthma is not entirely clear, but it often arises from a combination of genetic and environmental factors. These may include respiratory infections, allergens (pollen, mold, dust mites), pollutants (tobacco smoke, air pollution), occupational irritants, and lifestyle factors such as obesity and stress. Severe asthma can also develop in people whose milder asthma is not well-controlled over time.

Diagnosis of severe asthma begins with a comprehensive medical history, physical examination, and pulmonary function tests like spirometry to assess lung function. Doctors may also order additional tests, such as chest X-rays, blood tests, and allergy tests to identify triggers. A key factor in diagnosing severe asthma is the persistence of symptoms despite the optimal use of standard asthma treatments.

Managing severe asthma typically requires a multifaceted approach. Inhaled corticosteroids and long-acting bronchodilators are the mainstays of treatment. For those who do not respond to these medications, biologic therapies (such as omalizumab, mepolizumab, or dupilumab) may be prescribed to target specific pathways involved in the inflammatory response. In addition, patients with severe asthma may benefit from lifestyle modifications, including weight management, avoiding triggers, and pulmonary rehabilitation. In extreme cases, systemic corticosteroids may be necessary, although long-term use can have serious side effects.

Find out more about severe asthma treatment drugs @ Drugs for
Severe Asthma Treatment

A snapshot of the severe asthma Pipeline Drugs mentioned in the report:

Drugs	Company	Phase	MoA	RoA
GSK3511294	GlaxoSmithKline	III	Interleukin 5 receptor antagonists	Subcutaneous
CBP-201	Suzhou Connect Biopharmaceuticals	II	Interleukin 4 receptor alpha subunit antagonists	Subcutaneous
BSI-045B	Biosion	II	Thymic stromal lymphopoietin inhibitors	Subcutaneous
CM326	KeyMed Biosciences	II	Thymic stromal lymphopoietin inhibitors; Thymic stromal lymphopoietin modulators	Subcutaneous
FB 704A	Fountain BioPharma	II	Interleukin 6 inhibitors	Intravenous
KN 002	Kinaset Therapeutics	I	Tumour necrosis factor alpha inhibitors	Inhalation

Learn more about the emerging severe asthma pipeline therapies @ Severe Asthma Clinical Trials

Severe Asthma Therapeutics Assessment

The
severe asthma pipeline
report proffers an integral view of the severe asthma emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.

Scope of the Severe Asthma Pipeline Report

• Coverage :
  Global
  
• Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination
• Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
• Therapeutics Assessment
  By Route of Administration: Oral, Intravenous, Subcutaneous, Parenteral, Topical
• Therapeutics Assessment
  By Molecule Type : Recombinant fusion proteins, Small molecule, Monoclonal antibody, Peptide, Polymer, Gene therapy
• Therapeutics Assessment
  By Mechanism of Action: Interleukin 5 receptor antagonists, Thymic stromal lymphopoietin inhibitors, Thymic stromal lymphopoietin inhibitors, Thymic stromal lymphopoietin modulators, Interleukin 6 inhibitors, STAT6 transcription factor degraders, Interleukin 4 receptor alpha subunit antagonists
• Key Severe Asthma Companies : Kinaset Therapeutics, Bio-Thera Solutions, CSPC ZhongQi Pharmaceutical Technology, AB Science, GlaxoSmithKline, Oneness Biotech, Biosion, Lanier Biotherapeutics, Kymera Therapeutics, Suzhou Connect Biopharmaceuticals, Upstream Bio, Teva Branded Pharmaceutical Industries, Sanofi, Jiangsu Hengrui Medicine, AstraZeneca, Advagene Biopharma, Genrix (Shanghai) Biopharmaceuticals, and others.
• Key Severe Asthma Pipeline Therapies : KN-002, BAT2606, CM326, Masitinib, GSK3511294, FB 704A, BSI-045B, LNR 125.38, KT 621, CBP-201, Verekitug, TEV'248, Rilzabrutinib, SHR-1905, Atuliflapon, AD17002, GR1802, and others.

Dive deep into rich insights for new drugs for severe asthma treatment, visit
@ Severe Asthma Drugs

Table of Contents

1.	Severe Asthma Pipeline Report Introduction
2.	Severe Asthma Pipeline Report Executive Summary
3.	Severe Asthma Pipeline: Overview
4.	Analytical Perspective In-depth Commercial Assessment
5.	Severe Asthma Clinical Trial Therapeutics
6.	Severe Asthma Pipeline: Late-Stage Products (Pre-registration)
7.	Severe Asthma Pipeline: Late-Stage Products (Phase III)
8.	Severe Asthma Pipeline: Mid-Stage Products (Phase II)
9.	Severe Asthma Pipeline: Early-Stage Products (Phase I)
10.	Severe Asthma Pipeline Therapeutics Assessment
11.	Inactive Products in the Severe Asthma Pipeline
12.	Company-University Collaborations (Licensing/Partnering) Analysis
13.	Key Companies
14.	Key Products in the Severe Asthma Pipeline
15.	Unmet Needs
16.	Market Drivers and Barriers
17.	Future Perspectives and Conclusion
18.	Analyst Views
19.	Appendix

For further information on the severe asthma pipeline therapeutics, reach out @ Severe Asthma
Treatment Drugs

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