Stem Cell Transplant Hematologist Joins Karmanos Cancer Institute's BMT And Hematology Multidisciplinary Teams
Dr. Larios has research and clinical interests in the role of bone marrow microenvironment in leukemia progression. This includes bone marrow signaling in acute leukemias, stem cell transplantation, and cellular therapy. He completed his postdoctoral fellowship in a breast oncology and pharmacology lab at the University of Michigan and investigated molecular mechanisms of endocrine resistance in hormone receptor-positive breast cancer.
He recapitulated newly published mutations in the estrogen receptor gene using breast cancer cell lines as pre-clinical models. Additionally, Dr. Larios also examined mechanisms of resistance to CDK4/6 inhibitors.
"With Karmanos being an NCI-Designated Comprehensive Cancer Center, in partnership with Wayne State University, Dr. Larios' research and interests will lead to significant discovery in the way we currently treat leukemias and lymphomas with stem cell transplantation," explained George Yoo, M.D., FACS, Chief Medical Officer at Karmanos Cancer Hospital. "Having physicians that push the standard of care needle forward is just what we need in the fight against cancer, to help with future treatments that cure cancers and lead to a better quality of life after treatment."
In addition to his postdoctoral fellowship work, Dr. Larios completed an internal medicine residency at Ascension Providence Hospital in Southfield and received his medical degree at Ross University School of Medicine, which was in Dominica at that time. He is board-certified by the American Board of Internal Medicine, where he is also a diplomate in Internal Medicine. He is a member of the American Society of Hematology, the American Society of Clinical Oncology, and the American Medical Association. He serves on the editorial board for the European Journal of Neurology and has co-authored multiple peer-reviewed published studies.
View Dr. Lario's physician profile here . To request an appointment, visit karmanos or call 1-800-KARMANOS .
About the Barbara Ann Karmanos Cancer Institute
Karmanos Cancer Institute is a leader in transformative cancer care, research and education through courage, commitment and compassion. The Karmanos vision is a world free of cancer. As part of McLaren Health Care, Karmanos is the largest provider of cancer care and research in Michigan. For more than 75 years, the administrative and research headquarters, along with the premier specialty cancer hospital, have been located in downtown Detroit. With 16 network sites, Karmanos delivers world-renowned care and access to clinical trials throughout Michigan and northern Ohio. The National Cancer Institute recognizes Karmanos as one of the best cancer centers in the nation with a comprehensive cancer center designation. Its academic partnership with the Wayne State University School of Medicine provides the framework for cancer research and education – defining new standards of care and improving survivorship. For more information, call 1-800-KARMANOS (800-527-6266) or visit
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About the Bone Marrow & Stem Cell Transplantation Program at Karmanos
The Karmanos Cancer Institute Bone Marrow Transplantation (BMT) Program is one of only a select group nationwide reporting some of the best survival outcomes for related and unrelated stem cell transplantation, according to data released yearly from the Center for International Blood and Marrow Transplant Registry. In addition, the BMT program has received full accreditation from the
Foundation for the Accreditation of Cellular Therapy (FACT)
– the highest level and the most extensive spectrum of accreditation offered by FACT for Bone Marrow Transplant Programs. Members of the BMT Team have vast experience in clinical research focusing on graft-versus-host disease and immunotherapy. To learn more, click here .
SOURCE Karmanos Cancer Institute

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