(MENAFN- GlobeNewsWire - Nasdaq) Strong enthusiasm for novel modalities is tempered by neurologists' demands for clinically meaningful endpoints and data superiority, according to Spherix Global Insights.

EXTON, PA, Nov. 03, 2025 (GLOBE NEWSWIRE) -- Spherix Global Insights' latest Special TopixTM: Neurology Pipeline Opportunities 2025 (US) service captures forward-looking insights from 79 U.S. neurologists across five key neurological conditions-Amyotrophic Lateral Sclerosis (ALS), Parkinson's disease (PD), multiple sclerosis (MS), generalized myasthenia gravis (gMG), and chronic inflammatory demyelinating polyneuropathy (CIDP). Key findings reveal that despite a wide range of familiarity with investigational agents, neurologists share a clear message: they are ready to embrace innovation-provided new treatments deliver clinically meaningful outcomes on validated endpoints.

ALS is viewed as the most urgent area for therapeutic advancement, with 82% of neurologists stating that most of their ALS patients remain inadequately managed. Gene and cell-based therapies are seen as the most promising approaches to shift the treatment paradigm, with neurologists highlighting progression-free survival (PFS) as the most valuable benchmark for future therapies. Conceptual enthusiasm runs high, but adoption is expected to depend on clear efficacy signals, ideally demonstrating superiority over existing options.

In Parkinson's disease, neurologists prioritize improvements in MDS-UPDRS scores and time to confirmed worsening. Early-stage interest is building around novel assets such as Bemdaneprocel (a dopaminergic stem cell therapy) developed by BlueRock Therapeutics and BIIB122/DNL151, a LRRK2 inhibitor co-developed by Biogen and Denali Therapeutics. While the mechanisms are compelling, neurologists remain measured, with uptake contingent on rigorous clinical data and proven long-term benefit.

CAR-T therapies-including Descartes-08 (Cartesian Therapeutics) and KYV-101 (Kyverna Therapeutics)-are gaining traction in the neuroimmune segment, particularly for refractory cases of MS, gMG, and CIDP. Despite the novel approach and strong early efficacy signals, concerns remain around cytokine release syndrome (CRS), long-term safety, cost, and logistical complexity. One neurologist summarized the cautious outlook:“We need to see head-to-head comparisons, a robust safety profile, and meaningful clinical superiority.”

As the neurology pipeline matures, neurologists are increasingly open to combination strategies and multimodal approaches to address historically difficult-to-treat conditions. Even therapies with low initial awareness can gain momentum quickly-if they meet the expectations of specialists who prioritize measurable, practice-relevant outcomes. Spherix's findings highlight both the opportunity, and the evidence thresholds manufacturers must meet to drive adoption in this evolving, high-stakes therapeutic landscape.

About Special TopixTM
Special TopixTM is an independent service that includes access to a report or series of reports based on current events or topics of interest in specialty markets covered by Spherix.

About Spherix Global Insights

Spherix is a leading independent market intelligence and advisory firm that delivers commercial value to the global life sciences industry, across the brand lifecycle.

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CONTACT: Bob Shewbrooks, Neurology Franchise Head Spherix Global Insights 4848794284...

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