Moderate To Severe Atopic Dermatitis Clinical Trial Pipeline Insights Featuring 45+ Companies | Delveinsight

(MENAFN- GlobeNewsWire - Nasdaq) The moderate to severe atopic dermatitis market is experiencing strong growth driven by rising global prevalence and heightened awareness, fueling demand for advanced treatments. Breakthroughs in biologics, small molecules, and personalized medicine are reshaping the therapeutic landscape. A robust pipeline, frequent drug approvals, and supportive reimbursement frameworks further enhance market momentum. Additionally, innovations in pediatric care and improved global access continue to expand opportunities in this evolving space.

New York, USA, May 20, 2025 (GLOBE NEWSWIRE) -- Moderate to Severe Atopic Dermatitis Clinical Trial Pipeline Insights Featuring 45+ Companies | DelveInsight

The moderate to severe atopic dermatitis market is experiencing strong growth driven by rising global prevalence and heightened awareness, fueling demand for advanced treatments. Breakthroughs in biologics, small molecules, and personalized medicine are reshaping the therapeutic landscape. A robust pipeline, frequent drug approvals, and supportive reimbursement frameworks further enhance market momentum. Additionally, innovations in pediatric care and improved global access continue to expand opportunities in this evolving space.

DelveInsight's ' Moderate to Severe Atopic Dermatitis Pipeline Insight 2025 ' report provides comprehensive global coverage of pipeline moderate to severe atopic dermatitis therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the moderate to severe atopic dermatitis pipeline domain.

Key Takeaways from the Moderate to Severe Atopic Dermatitis Pipeline Report

• DelveInsight's moderate-to-severe atopic dermatitis pipeline report depicts a robust space with 45+ active players working to develop 50+ pipeline moderate-to-severe atopic dermatitis drugs.
• Key moderate to severe atopic dermatitis companies such as Jiangsu Vcare Pharmaceutical Technology Co., LTD, Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd., Nektar Therapeutics, E-nitiate Biopharmaceuticals (Hangzhou) Co., Ltd., Corvus Pharmaceuticals, Inc., UCB Biopharma SRL, Tavotek Biotherapeutics, Guangdong Hengrui Pharmaceutical Co., Ltd, SCM Lifescience Co., LTD., Sanofi, Amgen, Qurient Co., Ltd., Sun Pharmaceutical Industries Limited, Pfizer, UNION therapeutics, Bio-Thera Solutions, medac GmbH, Eli Lilly and Company, AbbVie, Lynk Pharmaceuticals Co., Ltd, LEO Pharma, Guangzhou JOYO Pharma Co., Ltd, Beijing InnoCare Pharma Tech Co., Ltd., Oneness Biotech Co., Ltd., Evommune, Inc. , Apogee Therapeutics, Kymera Therapeutics, and others are evaluating new moderate to severe atopic dermatitis drugs to improve the treatment landscape.
• Promising pipeline moderate to severe atopic dermatitis therapies such as VC005, TQH2722, Rezpegaldesleukin, QY201, Soquelitinib, UCB9741, TAVO101, SHR-1819, SCM-AGH, SAR444656, Rocatinlimab, Q301, SCD-044, PF-07832837, Orismilast, BAT6026, Methotrexate, LY3454738, Lutikizumab, LNK01001, LEO 138559, JYP0061, ICP-332, FB825, EVO301, APG777, KT-621, and others are in different phases of moderate to severe atopic dermatitis clinical trials.
• In April 2025, Kymera Therapeutics announced that it had recently initiated dosing in its BroADen Phase Ib clinical trial evaluating KT-621, an oral, highly selective, potent degrader of STAT6, in patients with moderate to severe atopic dermatitis (AD). The Company expects to report data from the BroADen trial in the fourth quarter of 2025.
• In April 2025, Corvus Pharmaceuticals announced that new interim data from the randomized, double-blind, placebo-controlled Phase I clinical trial evaluating soquelitinib in patients with moderate to severe atopic dermatitis will be presented in an oral session and poster at the Society for Investigative Dermatology.
• In February 2025, Apogee Therapeutics announced that the first patient had been dosed in the Part B portion of the Phase II APEX clinical trial of APG777 in patients with moderate-to-severe AD, as well as enrollment completion in the Part A portion of the trial.
• In February 2025, the FDA granted fast-track designation to rezpegaldesleukin for the treatment of patients 12 years and older with moderate-to-severe atopic dermatitis whose disease is not controlled with topical prescription therapies or for which those therapies are not advisable.
• In January 2025, Nektar Therapeutics announced that the company had completed target enrollment in its REZOLVE-AD Phase IIb study of rezpegaldesleukin in patients with moderate-to-severe atopic dermatitis.
• In December 2024, Corvus Pharmaceuticals announced interim data from the randomized, double-blind, placebo-controlled Phase I clinical trial evaluating soquelitinib in patients with moderate to severe atopic dermatitis.
• In December 2024, Celldex Therapeutics announced that the Company has initiated a Phase II study of barzolvolimab in moderate to severe atopic dermatitis and that the study is actively enrolling patients.
• In October 2024, LEO Pharma presented the final results of the five-year extension study ECZTEND, showing the long-term safety and efficacy profile of Adbry® (tralokinumab-ldrm) in adults and adolescent patients (aged 12 years and over) with moderate-to-severe atopic dermatitis (AD).
• In January 2024, Aclaris Therapeutics announced top-line results from its Phase IIb study of ATI-1777, an investigational topical “soft” JAK 1/3 inhibitor, in patients with mild to severe atopic dermatitis (AD) (ATI-1777-AD-202; NCT05432596). ATI-1777 was generated from Aclaris' proprietary KINect® drug discovery platform.

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The moderate to severe atopic dermatitis pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage moderate to severe atopic dermatitis drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the moderate to severe atopic dermatitis clinical trial landscape.

Moderate to Severe Atopic Dermatitis Overview

Atopic dermatitis is the most prevalent chronic inflammatory skin condition, often starting in infancy and marked by dry skin, eczema-like lesions, and thickened or leathery patches. It frequently occurs alongside other IgE-mediated conditions, such as asthma, allergic rhinitis, and food allergies. Over the last few decades, the incidence of atopic dermatitis has been on the rise, contributing to a high burden of disease. Moderate to severe cases are characterized by frequent flare-ups, intense itching, and skin changes like discoloration and raised, rough patches. In severe cases, persistent nighttime itching can disrupt sleep and daily life, worsening overall health and well-being. Beyond physical symptoms, atopic dermatitis can take a toll on mental health, often leading to anxiety, depression, and social discomfort due to the visible nature of the skin condition. Effective treatment typically involves a mix of skincare practices, medications, and lifestyle adjustments to manage flare-ups and improve patients' quality of life.

The underlying causes of moderate to severe atopic dermatitis are multifactorial, involving both genetic predispositions and environmental influences that disrupt skin barrier function and immune regulation. atopic dermatitis is part of the“atopic triad” along with asthma and allergic rhinitis, and often progresses through the“atopic march,” where symptoms develop sequentially over time. Many individuals with atopic dermatitis carry mutations in the filaggrin gene, which is vital for maintaining skin hydration, and these mutations may also increase susceptibility to other allergic conditions. Environmental triggers such as exposure to allergens like eggs, dairy, peanuts, and cigarette smoke can worsen symptoms, making disease control more complex. These genetic and environmental contributors explain the chronic and sometimes disabling nature of moderate to severe atopic dermatitis.

Moderate to severe atopic dermatitis presents with a variety of persistent and uncomfortable symptoms, including severe itching, red or discolored patches, and dry, flaky skin. Affected areas may crack, swell, ooze, and develop crusts. In more severe cases, symptoms can affect the entire body or flare up in localized areas such as the face, eyelids, neck, scalp, lips, ears, hands, feet, and behind the knees. The skin often becomes extremely sensitive, further intensifying discomfort and negatively affecting daily life.

Managing moderate to severe atopic dermatitis requires a comprehensive and personalized treatment strategy. This typically includes identifying and avoiding triggers, maintaining a consistent skincare routine, and using anti-inflammatory therapies. Daily moisturization is crucial-emollients should be applied twice daily, especially within three minutes after bathing, to lock in moisture. Topical corticosteroids are commonly used to control acute flare-ups, while nonsteroidal options like calcineurin inhibitors are preferred for delicate areas. When topical treatments are inadequate, systemic options such as phototherapy or immunosuppressive drugs like cyclosporine may be used.

Biologic therapies, notably dupilumab, target specific immune pathways by inhibiting IL-4 and IL-13 signaling and have shown significant benefits. Additional supportive treatments include dilute bleach baths to reduce skin bacterial load and the use of probiotics during pregnancy and breastfeeding to potentially lower the incidence of atopic dermatitis in children. Furthermore, crisaborole, a topical phosphodiesterase-4 (PDE-4) inhibitor, provides a non-steroidal option for treating mild to moderate forms of the disease.

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A snapshot of the Pipeline Moderate to Severe Atopic Dermatitis Drugs mentioned in the report:

Drugs	Company	Phase	MoA	RoA
VC005	Jiangsu Vcare Pharmaceutical Technology Co., LTD	III	Janus kinase 1 inhibitors	Topical
TQH2722	Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.	II	Interleukin 4 receptor type I antagonists; Interleukin-4 receptor type II antagonists	Subcutaneous
Rezpegaldesleukin	Nektar Therapeutics	II	Interleukin 2 modulators	Subcutaneous
TAVO101	Tavotek Biotherapeutics	II	Thymic stromal lymphopoietin modulators	Intravenous
QY201	E-nitiate Biopharmaceuticals (Hangzhou) Co., Ltd.	II	Janus kinase 1 inhibitors; TYK2 kinase inhibitors	Oral
UCB9741	UCB Biopharma	I/II	Immunomodulators	Intravenous
Soquelitinib	Corvus Pharmaceuticals, Inc.	I	Emt protein-tyrosine kinase inhibitors	Oral

Learn more about the emerging moderate to severe atopic dermatitis therapies @ Moderate to Severe Atopic Dermatitis Clinical Trials

Moderate to Severe Atopic Dermatitis Therapeutics Assessment

The moderate to severe atopic dermatitis pipeline report proffers an integral view of the emerging moderate to severe atopic dermatitis therapies segmented by stage, product type, molecule type, route of administration, and mechanism of action.

Scope of the Moderate to Severe Atopic Dermatitis Pipeline Report

• Coverage : Global
• Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination
• Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
• Therapeutics Assessment By Route of Administration: Oral, Intravenous, Subcutaneous, Parenteral, Topical
• Therapeutics Assessment By Molecule Type : Recombinant fusion proteins, Small molecule, Monoclonal antibody, Peptide, Polymer, Gene therapy
• Therapeutics Assessment By Mechanism of Action : Janus kinase 1 inhibitors, Interleukin 4 receptor type I antagonists, Interleukin-4 receptor type II antagonists, Interleukin 2 modulators, TYK2 kinase inhibitors, Emt protein-tyrosine kinase inhibitors, Immunomodulators, Thymic stromal lymphopoietin modulators, Interleukin 4 receptor alpha subunit antagonists
• Key Moderate to Severe Atopic Dermatitis Companies : Jiangsu Vcare Pharmaceutical Technology Co., LTD, Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd., Nektar Therapeutics, E-nitiate Biopharmaceuticals (Hangzhou) Co., Ltd., Corvus Pharmaceuticals, Inc., UCB Biopharma SRL, Tavotek Biotherapeutics, Guangdong Hengrui Pharmaceutical Co., Ltd, SCM Lifescience Co., LTD., Sanofi, Amgen, Qurient Co., Ltd., Sun Pharmaceutical Industries Limited, Pfizer, UNION therapeutics, Bio-Thera Solutions, medac GmbH, Eli Lilly and Company, AbbVie, Lynk Pharmaceuticals Co., Ltd, LEO Pharma, Guangzhou JOYO Pharma Co., Ltd, Beijing InnoCare Pharma Tech Co., Ltd., Oneness Biotech Co., Ltd., Evommune, Inc., Apogee Therapeutics, Kymera Therapeutics, and others.
• Key Moderate to Severe Atopic Dermatitis Pipeline Therapies : VC005, TQH2722, Rezpegaldesleukin, QY201, Soquelitinib, UCB9741, TAVO101, SHR-1819, SCM-AGH, SAR444656, Rocatinlimab, Q301, SCD-044, PF-07832837, Orismilast, BAT6026, Methotrexate, LY3454738, Lutikizumab, LNK01001, LEO 138559, JYP0061, ICP-332, FB825, EVO301, APG777, KT-621, and others.

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Table of Contents

1.	Moderate to Severe Atopic Dermatitis Pipeline Report Introduction
2.	Moderate to Severe Atopic Dermatitis Pipeline Report Executive Summary
3.	Moderate to Severe Atopic Dermatitis Pipeline: Overview
4.	Analytical Perspective In-depth Commercial Assessment
5.	Moderate to Severe Atopic Dermatitis Clinical Trial Therapeutics
6.	Moderate to Severe Atopic Dermatitis Pipeline: Late-Stage Products (Pre-registration)
7.	Moderate to Severe Atopic Dermatitis Pipeline: Late-Stage Products (Phase III)
8.	Moderate to Severe Atopic Dermatitis Pipeline: Mid-Stage Products (Phase II)
9.	Moderate to Severe Atopic Dermatitis Pipeline: Early-Stage Products (Phase I)
10.	Moderate to Severe Atopic Dermatitis Pipeline Therapeutics Assessment
11.	Inactive Products in the Moderate to Severe Atopic Dermatitis Pipeline
12.	Company-University Collaborations (Licensing/Partnering) Analysis
13.	Key Companies
14.	Key Products in the Moderate to Severe Atopic Dermatitis Pipeline
15.	Unmet Needs
16.	Market Drivers and Barriers
17.	Future Perspectives and Conclusion
18.	Analyst Views
19.	Appendix

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