Severe Asthma Clinical Trial Pipeline Appears Robust With 30+ Key Pharma Companies Actively Working In The Therapeutics Segment Delveinsight Delveinsight

Stuti Mahajan, consulting manager at DelveInsight, said that the rise in severe asthma cases propels demand for advanced treatment options, spurring innovation and investment in pharmaceutical research and development.

Recent Developments in Severe Asthma Treatment Space

• In February 2026, Upstream Bio, Inc., a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders, announced positive top-line results from the Phase II VALIANT clinical trial evaluating the safety and efficacy of verekitug in adults with severe asthma.
• In February 2026, in the pooled analysis of KALOS and LOGOS, BREZTRI also demonstrated clinically meaningful reductions in the annualized rate of severe asthma exacerbations versus ICS/LABA medicines in patients with or without a recent asthma exacerbation.
• In February 2026, Generate Biomedicines' lead asset, GB-0895, targets severe asthma and COPD, with Phase III enrollment expected to be completed by H2 2027.
• In January 2026, GSK announced that it had entered a multi-year strategic collaboration agreement with Helix, aiming to drive the development of precision medicines. The announcement comes on the heels of the FDA's approval of GSK's Exdensur for adolescents and adults with severe asthma characterized by an eosinophilic phenotype.
• In January 2026, A clinical trial to determine the best intravenous (IV) treatments for children with severe asthma will go ahead thanks to an almost $5 million Medical Research Future Fund grant. The clinical trial spearheaded by Professor Simon Craig, Adjunct Clinical Professor in the School of Clinical Sciences at Monash Health and paediatric emergency medicine physician at Monash Medical Centre, will provide clinicians with clear evidence to make more informed decisions, provide faster and more effective treatment, reduce unnecessary variation between hospitals, and ultimately improve outcomes for children with severe asthma.
• In December 2025, the FDA had approved GSK's Exdensur (depemokimab-ulaa) for the treatment of severe asthma as an add-on maintenance therapy in adult and pediatric patients 12 years and older.
• In December 2025, Generate Biomedicines announced its plans to initiate two global Phase III clinical trials, SOLAIRIA-1 and SOLAIRIA-2, evaluating GB-0895 in approximately 1,600 adults and adolescents with severe asthma whose disease remains inadequately managed on current therapies. GB-0895 is an investigational, long-acting monoclonal antibody engineered with AI to target thymic stromal lymphopoietin (TSLP), a key driver of airway inflammation. These studies will evaluate the efficacy of GB-0895 in reducing clinically significant asthma exacerbations over 52 weeks, the primary objective for both trials.

Scope of the Severe Asthma Pipeline Report

• Coverage: Global
• Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination
• Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
• Therapeutics Assessment By Route of Administration: Oral, Intravenous, Subcutaneous, Parenteral, Topical
• Therapeutics Assessment By Molecule Type: Recombinant fusion proteins, Small molecule, Monoclonal antibody, Peptide, Polymer, Gene therapy
• Therapeutics Assessment By Mechanism of Action: Antioxidants, Apoptosis inhibitors, Dopamine receptor agonists, Free radical scavengers, Thymic stromal lymphopoietin inhibitors, Interleukin 6 inhibitors, Interleukin 4 receptor alpha subunit antagonists, CRLF2 protein antagonists, Beta 2 adrenergic receptor agonists, Steroid receptor agonists, Interleukin 4 receptor antagonists, Interleukin 5 inhibitors
• Key Severe Asthma Companies: CSPC ZhongQi Pharmaceutical Technology, Oneness Biotech, Biosion, Suzhou Connect Biopharmaceuticals, Upstream Bio, Teva Branded Pharmaceutical Industries, Lanier Biotherapeutics, Nanjing RegeneCore Biotech Co., Ltd., AstraZeneca, Generate Biomedicines, Incyte Corporation, Shanghai Hengrui Pharmaceutical Co., Ltd., and others
• Key Severe Asthma Pipeline Therapies: CM326, FB704A, BSI-045B, CBP-201, Verekitug, TEV-56248, LNR 125.38, RC1416, Tezepelumab, GB-0895, Povorcitinib, CM310, SHR-1905 and others

Severe Asthma Drugs

Table of Contents

1.	Severe Asthma Pipeline Report Introduction
2.	Severe Asthma Pipeline Report Executive Summary
3.	Severe Asthma Pipeline: Overview
4.	Analytical Perspective In-depth Commercial Assessment
5.	Severe Asthma Clinical Trial Therapeutics
6.	Severe Asthma Pipeline: Late-Stage Products (Pre-registration)
7.	Severe Asthma Pipeline: Late-Stage Products (Phase III)
8.	Severe Asthma Pipeline: Mid-Stage Products (Phase II)
9.	Severe Asthma Pipeline: Early-Stage Products (Phase I)
10.	Severe Asthma Pipeline Therapeutics Assessment
11.	Inactive Products in the Severe Asthma Pipeline
12.	Company-University Collaborations (Licensing/Partnering) Analysis
13.	Key Companies
14.	Key Products in the Severe Asthma Pipeline
15.	Unmet Needs
16.	Market Drivers and Barriers
17.	Future Perspectives and Conclusion
18.	Analyst Views
19.	Appendix

For further information on the severe asthma cure research, reach out @ Medication for Severe Asthma Treatment

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