AGIO Stock Cracks After Sickle-Cell Disease Drug Delivers Mixed Results In Late-Stage Trial

2025-11-19 10:13:08

(MENAFN- AsiaNet News)

Shares of Agios Pharmaceuticals, Inc. (AGIO) slumped 49% in the pre-market session on Wednesday after the company reported mixed results from its drug trial in sickle cell disease.

The company said that the late-stage study of Mitapivat in patients aged 16 years and older with sickle cell disease met the primary endpoint of hemoglobin response, with the drug demonstrating a statistically significant improvement compared to placebo.

Hemoglobin response is defined as an increase from baseline in average hemoglobin in a particular time frame.

While Mitapivat also showed a reduction in the primary endpoint of annualized rate of sickle cell pain crises (SCPCs) compared to placebo, this trend did not achieve statistical significance, the company noted.

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