Nial Wheate

(MENAFN- The Conversation) Professor, School of Natural Sciences, Macquarie University Profile Articles Activity

Professor Wheate completed a Bachelor of Science (BSc) degree with 1st class honours from the University of New South Wales whilst at the Australian Defence Force Academy (1998) before he completed a Doctor of Philosophy (PhD) in medicinal chemistry under Professor J. Grant Collins (2002). He has since been awarded a Doctor of Science (DSc) in 2020 and a Master of Business Administration (MBA) in 2021 both from The University of Sydney.

Since completing his PhD in 2002, he has worked in the School of Biomedical and Health Sciences at Western Sydney University (2005-2007) and the Strathclyde Institute of Pharmacy and Biomedical Science in Scotland (2007-2011) before taking up a position in the Faculty of Pharmacy at the University of Sydney (Australia) in 2012. During this time, he held roles as Program Director of the pharmacy undergraduate degrees, Head of Cancer Research, and MPharm Director.

Currently he is a professor in the School of National Sciences at Macquarie University.

Experience

• 2024–present Professor, Macquarie University
• 2018–2024 Associate Professor, University of Sydney
• 2012–2017 Senior Lecturer, University of Sydney
• 2007–2011 Lecturer, University of Strathclyde
• 2005–2007 Senior Research Fellow, University of Western Sydney
• 2002–2005 Lieutenant, Royal Australian Navy
• 2001–2002 Associate Lecturer, University of New South Wales
• 1999–2001 Sub-Lieutenant, Royal Australian Navy
• 1995–1998 Midshipman, Royal Australian Navy

Education

• 2021 University of Sydney, MBA
• 2020 University of Sydney, DSc
• 2002 University of New South Wales, PhD
• 1998 University of New South Wales, BSc (Hons I)
• 1997 Australian Defence Force Academy, Graduate

Publications

• 2021 Microplastic in pharmaceutical dosage forms and patient informed consent, Australian Journal of Medical Sciences
• 2021 Macrocycles as drug-enhancing excipients in pharmaceutical formulations, Journal of Inclusion Phenomena and Macrocyclic Chemistry
• 2021 Opioid exposures in children under 5 years of age (2004–2019):A retrospective study of calls to Australia's largest poisonsinformation centre, Journal of Paediatrics and Child Health
• 2021 An analysis for adulteration and contamination of over-the-counter weight-loss products, AAPS PharmSciTech
• 2020 Demonstration of the first known 1:2 host‐guest encapsulation of a platinum anticancer complex within a macrocycle, Journal of Inclusion Phenomena and Macrocyclic Chemistry
• 2019 Analysis of the interaction of para-sulfonatocalix[8]arene with free amino acids and a six residue segmentof β-amyloid peptide as a potential treatment for Alzheimer's disease, Journal of Inclusion Phenomena and Macrocyclic Chemistry
• 2018 The side effects of platinum-based chemotherapy drugs: a review for chemists, Dalton Transactions
• 2018 An evaluation of garlic products available in Australian pharmacies–From the label to the laboratory, Journal of Herbal Medicine
• 2018 Patterns of platinum drug use in an acute care setting: a retrospective study, Journal of Cancer Research and Clinical Oncology
• 2018 Demonstration of In Vitro Host-Guest Complex Formation and Safety of para-Sulfonatocalix[8]arene as a Delivery Vehicle for Two Antibiotic Drugs, Journal of Pharmaceutical Sciences
• 2017 Determining the Ibuprofen Concentration in Liquid-Filled Gelatin Capsules To Practice Collecting and Interpreting Experimental Data, and Evaluating the Methods and Accuracy of Quality Testing, Journal of Chemical Education
• 2017 Comparative macrocycle binding of the anticancer drug phenanthriplatin by cucurbit[n]urils, β-cyclodextrin and parasulfonatocalix[ 4]arene: a 1H NMR and molecular modelling study, Journal of Inclusion Phenomena and Macrocyclic Chemistry
• 2016 Cucurbit[n]urils as excipients in pharmaceutical dosage forms, Supramolecular Chemistry
• 2016 Loading of a Phenanthroline-Based Platinum(II) Complex onto the Surface of a Carbon Nanotube via pi–pi Stacking, Australian Journal of Chemistry
• 2016 Host-Guest Complexes of Carboxylated Pillar[n]arenes With Drugs, Journal of Pharmaceutical Sciences
• 2016 Executive functions predict conceptual learning of science, British Journal of Developmental Psychology
• 2015 The state-of-play- and future of platinum drugs, Endocrine-Related Cancer
• 2015 Cucurbit[7]uril encapsulated cisplatin overcomes resistance to cisplatin induced by Rab25 overexpression in an intraperitoneal ovarian cancer model, Journal of Ovarian Research
• 2014 Analysis of montmorillonite clay as a vehicle in platinum anticancer drug delivery, Inorganica Chimica Acta
• 2014 Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents, Journal of Visualized Experiments
• 2014 The ex vivo neurotoxic, myotoxic and cardiotoxic activity of cucurbituril-based macrocyclic drug delivery vehicles, Toxicology Research
• 2014 Chemical factors affecting cucurbit[n]uril formulation into ocular dosage forms: excipient binding, solubility, corneal permeability and antibiotic encapsulation, Supramolecular Chemistry
• 2014 Topical Cream-Based Dosage Forms of the Macrocyclic Drug Delivery Vehicle Cucurbit[6]uril, PLoS One
• 2014 A cisplatin slow-release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol, Journal of Inorganic Biochemistry
• 2013 DNA-based aptamer fails as a simultaneous cancer targeting agent and drug delivery vehicle for a phenanthroline-based platinum(II) complex, Journal of Inorganic Biochemistry
• 2013 Platinum anticancer drugs, Encyclopedia of Metalloproteins
• 2013 Evidence for a Role of Executive Functions in Learning Biology, Infant and Child Development
• 2012 Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect, Metallomics
• 2012 Cisplatin drug delivery using gold-coated iron oxide nanoparticles for enhanced tumour targeting with external magnetic fields, Inorganica Chimica Acta
• 2012 Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity, Dalton Transactions
• 2012 Nanoparticles: the future for platinum drugs or a research red herring?, Nanomedicine
• 2012 Cisplatin-Tethered Gold Nanoparticles That Exhibit Enhanced Reproducibility, Drug Loading, and Stability: a Step Closer to Pharmaceutical Approval?, Inorganic Chemistry
• 2012 Rationalising sequence selection by ligand assemblies in the DNA minor groove: the case for thiazotropsin A, Chemical Science
• 2012 Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery, Pharmaceutical Research
• 2012 Folding of dinuclear platinum anticancer complexes within the cavity of para-sulphonatocalix[4]arene, Inorganica Chimica Acta

Professional Memberships

• Fellow and Chartered Chemist of the Royal Australian Chemical Institute
• Member of the Australian Institute of Company Directors
• Senior Fellow of the Higher Education Academy

Research Areas

• Pharmacology And Pharmaceutical Sciences (1115)
• Medicinal And Biomolecular Chemistry (0304)

Honours

Australian Defence Medal (2007), The National Medal (2017), Nyholm Lecturer (2018), The Australian Research Awards Best in Field - Inorganic Chemistry (2023), John Martin Memorial Award (2024)

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