Glioblastoma Market, An Area With High Trial Failure And Unmet Need Is Expected To Witness Significant Growth Owing To Increased Usage Of Bevacizumab, Temozolimide, Optune Gio Along With Emergence Of New Class Of Therapies | Delveinsight
| Glioblastoma Report Metrics | Details |
| Study Period | 2020–2034 |
| Glioblastoma Report Coverage | 7MM [The United States, the EU-4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan] |
| Key Glioblastoma Companies | Novocure, Roche, Merck, Bayer, Daiichi Sankyo, Novartis, Laminar Pharmaceuticals, BioMimetix, Enterome, Genenta Science, Medicenna Therapeutics, Bayer, Chimerix, Aivita Biomedical, Denovo Biopharma, Northwest Biotherapeutics, MedImmune, DNAtrix, Imvax, MimiVax, CNS Pharmaceuticals, Oblato, Enterome, VBI Vaccines, and others |
| Key Glioblastoma products | Optune, AVASTIN, TEMODAR/TEMODAL, LAM561, BMX-001, EO2401, Temferon, MDNA55, Regorafenib, ONC201, AV-GBM-1, Enzastaurin (DB-102), DCVax-L, MEDI4736 (durvalumab), DNX-2401, IGV-001, SurVaxM, Berubicin, OKN-007, EO2401, VBI-1901, and others |
Scope of the Glioblastoma Market Report
- Glioblastoma Therapeutic Assessment: Glioblastoma current marketed and emerging therapies Glioblastoma Market Dynamics: Conjoint Analysis of Emerging Glioblastoma Drugs Competitive Intelligence Analysis: SWOT analysis and Market entry strategies Unmet Needs, KOL's views, Analyst's views, Glioblastoma Market Access and Reimbursement
Discover more about glioblastoma drugs in development @ Glioblastoma Clinical Trials
Table of Contents
| 1 | Key Insights |
| 2 | Report Introduction |
| 3 | Executive Summary |
| 4 | Key Events |
| 5 | Epidemiology and Market Forecast Methodology |
| 6 | GBM Market Overview at a Glance |
| 6.1 | Market Share (%) Distribution of GBM by Therapies in 2020 |
| 6.2 | Market Share (%) Distribution of GBM by Therapies in 2034 |
| 7 | Disease Background and Overview: GBM |
| 7.1 | Introduction |
| 7.2 | Classification of GBM |
| 7.3 | Glioblastoma Types |
| 7.3.1 | Astrocytomas |
| 7.3.2 | Ependymomas |
| 7.3.3 | Oligodendrogliomas |
| 7.3.4 | Mixed gliomas |
| 7.3.5 | Optic pathway gliomas |
| 7.4 | Symptoms |
| 7.5 | Causes |
| 7.6 | Pathophysiology |
| 7.6.1 | Macroscopic and Histological Features of GBM |
| 7.6.2 | Genetic and Molecular Pathogenesis |
| 7.7 | Inheritance of GBM |
| 7.7.1 | Genetic Variations of GBM |
| 7.7.2 | Isocitrate dehydrogenase mutations |
| 7.7.3 | O (6)-Methylguanine-DNA methyltransferase promoter methylation |
| 7.7.4 | Telomerase reverse transcriptase promoter mutations |
| 7.7.5 | Epidermal growth factor receptor aberrations |
| 7.7.6 | PTEN alterations |
| 7.7.7 | Other novel genetic aberrations |
| 7.8 | Molecular Classification |
| 7.8.1 | Specific Molecular Biomarkers |
| 7.9 | Diagnosis |
| 8 | Treatment and Management |
| 8.1 | Treatment Guidelines |
| 8.1.1 | NCCN Guidelines for Central Nervous System Cancers (Glioblastoma) (2024) |
| 8.1.2 | ESTRO-EANO Guideline on Target Delineation and Radiotherapy Details for Glioblastoma (2023) |
| 8.1.3 | Guidelines for the Management of Newly Diagnosed GBM (National Institute for Health and Care Excellence [NICE], 2021) |
| 8.1.4 | Clinical Recommendation for Glioblastoma (Associazione Italiana di Oncologia Medica [AIOM], 2021) |
| 8.1.5 | Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions (2020) |
| 8.1.6 | Guidelines for the Treatment of Adult GBM (Japanese Society of Neurological Surgery, 2019) |
| 8.1.7 | SEOM (Medical Oncology Spanish Society) Clinical Guidelines for Diagnosis and Treatment of GBM (2018) |
| 9 | Epidemiology and Patient Population |
| 9.1 | Key Findings |
| 9.2 | Assumptions and Rationale |
| 9.3 | Total Incident Cases of GBM in the 7MM |
| 9.4 | The US |
| 9.4.1 | Total Incident Cases of GBM in the US |
| 9.4.2 | Gender-specific Incident Cases of GBM in the US |
| 9.4.3 | Type-specific Incident Cases of GBM in the US |
| 9.4.4 | Incident Cases based on Primary Site of GBM in the US |
| 9.4.5 | Age-specific Incident Cases of GBM in the US |
| 9.4.6 | Incident Cases based on Histologic Classification of GBM in the US |
| 9.4.7 | Unmethylation of the MGMT Gene Promoter Cases in the US |
| 9.4.8 | BRAF V600E Mutation Cases in GBM in the US |
| 9.4.9 | Line-wise Treated Pool of GBM in the US |
| 9.5 | EU4 and the UK |
| 9.5.1 | Total Incident Cases of GBM in EU4 and the UK |
| 9.5.2 | Gender-specific Incident Cases of GBM in EU4 and the UK |
| 9.5.3 | Type-specific Incident Cases of GBM in EU4 and the UK |
| 9.5.4 | Incident Cases based on Primary Site of GBM in EU4 and the UK |
| 9.5.5 | Age-specific Incident Cases of GBM in EU4 and the UK |
| 9.5.6 | Incident Cases based on Histologic Classification of GBM in EU4 and the UK |
| 9.5.7 | Unmethylation of the MGMT Gene Promoter Cases in EU4 and the UK |
| 9.5.8 | BRAF V600E Mutation Cases in GBM in EU4 and the UK |
| 9.5.9 | Line-wise Treated Pool of GBM in EU4 and the UK |
| 9.6 | Japan |
| 9.6.1 | Total Incident Cases of GBM in Japan |
| 9.6.2 | Gender-specific Incident Cases of GBM in Japan |
| 9.6.3 | Type-specific Incident Cases of GBM in Japan |
| 9.6.4 | Incident Cases based on Primary Site of GBM in Japan |
| 9.6.5 | Age-specific Incident Cases of GBM in Japan |
| 9.6.6 | Incident Cases based on Histologic Classification of GBM in Japan |
| 9.6.7 | Unmethylation of the MGMT Gene Promoter Cases in Japan |
| 9.6.8 | BRAF V600E Mutation Cases in GBM in Japan |
| 9.6.9 | Line-wise Treated Pool of GBM in Japan |
| 10 | Patient Journey |
| 11 | Key Endpoints |
| 12 | Marketed Drugs |
| 12.1 | Key Competitors |
| 12.2 | AVASTIN (bevacizumab): Roche (Genentech) |
| 12.2.1 | Product Description |
| 12.2.2 | Regulatory Milestones |
| 12.2.3 | Other Developmental Activities |
| 12.2.4 | Safety and Efficacy |
| 12.3 | TEMODAR/TEMODAL (temozolomide): Merck |
| 12.3.1 | Product Description |
| 12.3.2 | Regulatory Milestones |
| 12.3.3 | Clinical Development |
| 12.3.4 | Safety and Efficacy |
| 12.4 | DELYTACT (teserpaturev/G47∆): Daiichi Sankyo |
| 12.4.1 | Product Description |
| 12.4.2 | Regulatory Milestones |
| 12.4.3 | Safety and Efficacy |
| 12.5 | TAFINLAR/FINLEE (dabrafenib) + MEKINIST (trametinib): Novartis |
| 12.5.1 | Product Description |
| 12.5.2 | Regulatory Milestones |
| 12.5.3 | Other Developmental Activities |
| 12.5.4 | Safety and Efficacy |
| 12.6 | OPTUNE GIO: Novocure |
| 12.6.1 | Product Description |
| 12.6.2 | Regulatory Milestones |
| 12.6.3 | Other Developmental Activities |
| 12.6.4 | Clinical Development |
| 12.6.5 | Safety and Efficacy |
| 12.7 | STIVARGA (regorafenib): Bayer |
| 12.7.1 | Product description |
| 12.7.2 | Regulatory Milestones |
| 12.7.3 | Other developmental activities |
| 12.7.4 | Clinical development |
| 12.7.5 | Safety and Efficacy |
| 13 | Emerging Drugs |
| 13.1 | Key Competitors |
| 13.2 | AV-GBM-1: Aivita Biomedical and TAE Life Sciences |
| 13.2.1 | Product Description |
| 13.2.2 | Other Developmental Activities |
| 13.2.3 | Clinical Development |
| 13.2.4 | Safety and Efficacy |
| 13.3 | DB107 (vocimagene amiretrorepvec-flucytosine): Denovo Biopharma |
| 13.3.1 | Product Description |
| 13.3.2 | Other Development Activities |
| 13.3.3 | Clinical Development |
| 13.4 | DCVax-L: Northwest Biotherapeutics and Advent BioServices |
| 13.4.1 | Product Description |
| 13.4.2 | Other Developmental Activities |
| 13.4.3 | Clinical Development |
| 13.4.4 | Safety and Efficacy |
| 13.5 | Eflornithine: Orbus Therapeutics |
| 13.5.1 | Product Description |
| 13.5.2 | Other Developmental Activities |
| 13.5.3 | Clinical Development |
| 13.6 | TVI-Brain-1: TVAX Biomedical |
| 13.6.1 | Product Description |
| 13.6.2 | Other Developmental Activities |
| 13.6.3 | Clinical Development |
| 13.7 | LAM561 (2-OHOA): Laminar Pharmaceuticals |
| 13.7.1 | Product Description |
| 13.7.2 | Other Developmental Activities |
| 13.7.3 | Clinical Development |
| 13.7.4 | Safety and Efficacy |
| 13.8 | VT1021: Vigeo Therapeutics |
| 13.8.1 | Product Description |
| 13.8.2 | Other Developmental Activities |
| 13.8.3 | Clinical Development |
| 13.8.4 | Safety and Efficacy |
| 13.9 | VERZENIO (abemaciclib, LY2835219): Eli Lilly and Company |
| 13.9.1 | Product Description |
| 13.9.2 | Other Development Activities |
| 13.9.3 | Clinical Development |
| 13.9.4 | Safety and Efficacy |
| 13.10 | PEMAZYRE (pemigatinib): Incyte Corporation |
| 13.10.1 | Product Description |
| 13.10.2 | Other Development Activities |
| 13.10.3 | Clinical Development |
| 13.11 | Paxalisib (GDC-0084): Kazia Therapeutics |
| 13.11.1 | Product Description |
| 13.11.2 | Other Developmental Activities |
| 13.11.3 | Clinical Development |
| 13.11.4 | Safety and Efficacy |
| 13.12 | BMX-001: BioMimetix |
| 13.12.1 | Product Description |
| 13.12.2 | Other Developmental Activities |
| 13.12.3 | Clinical Development |
| 13.12.4 | Safety and Efficacy |
| 13.13 | Bizaxofusp (MDNA55): Medicenna Therapeutics |
| 13.13.1 | Product Description |
| 13.13.2 | Other Developmental Activities |
| 13.13.3 | Clinical Development |
| 13.13.4 | Safety and Efficacy |
| 13.14 | ITI-1000 (pp65 DC Vaccine): Immunomic Therapeutics |
| 13.14.1 | Product Description |
| 13.14.2 | Other Developmental Activities |
| 13.14.3 | Clinical Development |
| 13.14.4 | Safety and Efficacy |
| 13.15 | SurVaxM: MimiVax |
| 13.15.1 | Product Description |
| 13.15.2 | Other Developmental Activities |
| 13.15.3 | Clinical Development |
| 13.15.4 | Safety and Efficacy |
| 13.16 | OKN-007: Oblato |
| 13.16.1 | Product Description |
| 13.16.2 | Other developmental Activities |
| 13.16.3 | Clinical Development |
| 13.16.4 | Safety and efficacy |
| 13.17 | Berubicin: CNS Pharmaceuticals |
| 13.17.1 | Product Description |
| 13.17.2 | Other Developmental Activities |
| 13.17.3 | Clinical Development |
| 13.17.4 | Safety and Efficacy |
| 13.18 | IGV-001: Imvax |
| 13.18.1 | Product Description |
| 13.18.2 | Other Developmental Activities |
| 13.18.3 | Clinical Development |
| 13.18.4 | Safety and efficacy |
| 13.19 | BGB-290 (pamiparib): Beigene |
| 13.19.1 | Product Description |
| 13.19.2 | Clinical Development |
| 13.19.3 | Safety and Efficacy |
| 13.20 | EO2401: Enterome |
| 13.20.1 | Product Description |
| 13.20.2 | Other Developmental Activities |
| 13.20.3 | Clinical Development |
| 13.20.4 | Safety and Efficacy |
| 13.21 | VBI-1901: VBI Vaccines |
| 13.21.1 | Product Description |
| 13.21.2 | Other Developmental Activities |
| 13.21.3 | Clinical Development |
| 13.21.4 | Safety and Efficacy |
| 13.22 | Temferon: Genenta Science |
| 13.22.1 | Product Description |
| 13.22.2 | Other Development Activities |
| 13.22.3 | Clinical Development |
| 13.22.4 | Safety and Efficacy |
| 13.23 | NOX-A12 (olaptesed pegol): TME Pharma |
| 13.23.1 | Product Description |
| 13.23.2 | Other Developmental Activities |
| 13.23.3 | Clinical Development |
| 13.23.4 | Safety and Efficacy |
| 13.24 | INO-5401 + INO-9012 + LIBTAYO (cemiplimab): Inovio Pharmaceuticals and Regeneron Pharmaceuticals |
| 13.24.1 | Product Description |
| 13.24.2 | Other Developmental Activities |
| 13.24.3 | Clinical Development |
| 13.24.4 | Safety and Efficacy |
| 13.25 | Lerapolturev: Istari Oncology and FUJIFILM Diosynth Biotechnologies |
| 13.25.1 | Product Description |
| 13.25.2 | Other Developmental Activities |
| 13.25.3 | Clinical Development |
| 13.25.4 | Safety and Efficacy |
| 13.26 | Rhenium (186Re) obisbemeda: Plus Therapeutics |
| 13.26.1 | Product Description |
| 13.26.2 | Other Developmental Activities |
| 13.26.3 | Clinical Development |
| 13.26.4 | Safety and Efficacy |
| 14 | GBM: Seven Major Market Analysis |
| 14.1 | Key Findings |
| 14.2 | Market Outlook |
| 14.3 | Conjoint Analysis |
| 14.4 | Key Market Forecast Assumptions |
| 14.5 | Total Market Size of GBM in the 7MM |
| 14.6 | The US Market Size |
| 14.6.1 | Total Market Size of GBM in the US |
| 14.6.2 | Market Size of GBM by Therapies in the US |
| 14.7 | EU4 and the UK Market Size |
| 14.7.1 | Total Market Size of GBM in EU4 and the UK |
| 14.7.2 | Market Size of GBM by Therapies in EU4 and the UK |
| 14.8 | Japan Market Size |
| 14.8.1 | Total Market Size of GBM in Japan |
| 14.8.2 | Market Size of GBM by Therapies in Japan |
| 15 | Unmet Needs |
| 16 | SWOT Analysis |
| 17 | KOL Views |
| 18 | Market Access and Reimbursement |
| 18.1 | United States |
| 18.1.1 | Centre for Medicare and Medicaid Services (CMS) |
| 18.2 | EU4 and the UK |
| 18.2.1 | Germany |
| 18.2.2 | France |
| 18.2.3 | Italy |
| 18.2.4 | Spain |
| 18.2.5 | United Kingdom |
| 18.3 | Japan |
| 18.3.1 | MHLW |
| 18.4 | Market Access and Reimbursement of GBM |
| 19 | Appendix |
| 19.1 | Bibliography |
| 19.2 | Report Methodology |
| 20 | DelveInsight Capabilities |
| 21 | Disclaimer |
| 22 | About DelveInsight |
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