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Novel study reveals method to inhibit cancer
(MENAFN) A groundbreaking study by the Children's Medical Research Institute (CMRI) in Sydney, released on Monday, has uncovered a new method by which cells protect themselves against cancer.
The research highlights the significant role telomeres, which are protective caps at the ends of chromosomes, play in both aging process and cancer protection.
As telomeres naturally shorten over the course of time, they send signals to aging cells to cease splitting, which is an essential mechanism in preventing cancer. However, the new study shows that telomeres are more active than previously thought.
Tony Cesare, a researcher at CMRI's Genome Integrity Unit, stated: "Our data shows telomeres are much more active. They can acutely respond to stress and actively open up to turn on a cellular response that looks like aging. They do this to avoid cancer."
Both Cesare and his group collaborated with researchers at the University of Kyoto to explore the "active" role telomeres play in this process.
The research, released in Nature Communications, uncovered that telomeres are not just passive entities that shorten over time. They actively respond to stress, triggering cellular aging processes that act as a defense mechanism against cancer development.
Cesare explained, "Most people think of telomeres as a passive entity that shortens with cell division. This is a passive fail-safe used during aging."
By initiating cell cycle arrest or programmed cell death, telomeres effectively remove damaged cells before they can divide uncontrollably. This finding introduces a novel, anti-cancer role for telomeres previously unknown to science.
The research highlights the significant role telomeres, which are protective caps at the ends of chromosomes, play in both aging process and cancer protection.
As telomeres naturally shorten over the course of time, they send signals to aging cells to cease splitting, which is an essential mechanism in preventing cancer. However, the new study shows that telomeres are more active than previously thought.
Tony Cesare, a researcher at CMRI's Genome Integrity Unit, stated: "Our data shows telomeres are much more active. They can acutely respond to stress and actively open up to turn on a cellular response that looks like aging. They do this to avoid cancer."
Both Cesare and his group collaborated with researchers at the University of Kyoto to explore the "active" role telomeres play in this process.
The research, released in Nature Communications, uncovered that telomeres are not just passive entities that shorten over time. They actively respond to stress, triggering cellular aging processes that act as a defense mechanism against cancer development.
Cesare explained, "Most people think of telomeres as a passive entity that shortens with cell division. This is a passive fail-safe used during aging."
By initiating cell cycle arrest or programmed cell death, telomeres effectively remove damaged cells before they can divide uncontrollably. This finding introduces a novel, anti-cancer role for telomeres previously unknown to science.
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