GLP-1 Ras & Incretin-Based Therapies Competitive Landscape Analysis: Key Developments By 200+ Companies Shaping The Treatment Landscape Delveinsight

A snapshot of the Pipeline GLP-1 RAs & Incretin-based Therapies mentioned in the report:

Arunima Dabral, Assistant Project Manager of Competitive Intelligence and Consulting at DelveInsight, said that GLP-1 receptor agonists represent an evolving therapeutic class in type 2 diabetes and obesity, with clinical research exploring their role in cardiovascular, renal, and other metabolic conditions. The development landscape includes oral formulations, dual and triple agonists, and agents designed to improve weight reduction and treatment tolerability. Market adoption varies across regions, influenced by pricing, reimbursement policies, treatment access, and patient adherence. Future developments will depend on clinical outcomes, long-term safety evidence, real-world effectiveness, and the ability of emerging therapies to address existing treatment gaps.

Recent Developments in the GLP-1 RAs & Incretin-based Therapies Treatment Space

• In October 2026, Zealand Pharma A/S announced that Boehringer Ingelheim has reported positive results from the Phase III SYNCHRONIZE-2 trial, which investigates the glucagon/GLP-1 receptor dual agonist survodutide (BI 456906) in adults living with obesity or overweight and type 2 diabetes (T2D). The trial met its co-primary endpoints, which were % change in body weight from baseline and body weight reduction of ≥5% from baseline, using both the treatment-regimen and efficacy estimands.
• In September 2026, Eli Lilly and Company announced detailed results from TRIUMPH-2, a Phase 3 trial evaluating the efficacy and safety of retatrutide, an investigational, first-in-class GIP, GLP-1, and glucagon triple hormone receptor agonist, in adults with type 2 diabetes and obesity or overweight. At 80 weeks, all doses of retatrutide (4 mg, 9 mg, and 12 mg) delivered substantial weight loss and reductions in A1C. Results were presented at the 62nd Annual Meeting of the European Association for the Study of Diabetes (EASD) in Milan, Italy, and simultaneously published in The Lancet.
• In August 2026, Neurocrine Biosciences, Inc. announced the initiation of a Phase I first-in-human clinical study evaluating the safety and tolerability of NBIP-'1968, an investigational GLP-1/GIP/glucagon receptor triple agonist being developed as a therapy for obesity.
• In June 2026, Hansoh Pharmaceutical Group Company Limited announced that the New Drug Application (NDA) for the Group's innovative drug Olatorepatide Injection has been accepted by the National Medical Products Administration (NMPA) of China for chronic weight management in obese and overweight adult patients.
• In May 2026, Eli Lilly and Company, the maker of Zepbound (tirzepatide) and Foundayo (orforglipron), announced positive topline results from TRIUMPH-1, a Phase III clinical trial evaluating the efficacy and safety of retatrutide, an investigational, first-in-class GIP, GLP-1, and glucagon triple hormone receptor agonist, in adults with obesity or overweight and at least one weight-related comorbidity and without diabetes. At 80 weeks, all doses of retatrutide (4 mg, 9 mg, and 12 mg) met the primary and key secondary endpoints for obesity, delivering clinically meaningful weight loss.
• In April 2026, 4Moving Biotech (4MB) announced that the US Food and Drug Administration (FDA) has granted Fast Track Designation to 4P004 for the treatment of knee osteoarthritis in patients with synovitis who have not benefited from at least two prior pharmacological therapies.
• In April 2026, MetaVia Inc. announced that the first patient has been dosed in Part 3 of its Phase I clinical trial evaluating DA-1726, a novel dual oxyntomodulin (OXM) analog targeting both GLP-1 (GLP1R) and glucagon (GCGR) receptors. Part 3 of the Phase I program consists of two 16-week titration cohorts designed to evaluate one-step and two-step dose-escalation strategies to safely achieve higher target doses and further optimize tolerability.
• In February 2026, Hangzhou Sciwind Biosciences Co., Ltd. announced a strategic commercialization collaboration with Pfizer China for Ecnoglutide injection (Ecnoglutide), a new‐generation cAMP‐biased GLP‐1 receptor agonist. Under the agreement, Pfizer will obtain exclusive commercialization rights for the product in Mainland China, marking an important first step to advance Pfizer's global strategy in the metabolic field in China. Sciwind Biosciences will remain the Marketing Authorization Holder and will be responsible for research and development, registration, manufacturing, and supply of the product. Under the terms of the agreement, Sciwind Biosciences is eligible to receive up to USD 495M in upfront, regulatory and sales milestone payments.
• In February 2026, Pfizer Inc. announced positive topline results from the Phase IIb VESPER-3 study investigating monthly maintenance dosing of its fully-biased, ultra-long-acting, injectable GLP-1 receptor agonist (RA) PF'3944 (MET-097i) in adults with obesity or overweight without type 2 diabetes.
• In January 2026, Roche announced positive topline results from CT388-103, a Phase II clinical trial of CT-388, an investigational dual GLP-1/GIP receptor agonist being developed for the treatment of obesity.
• In January 2026, AstraZeneca strengthened its weight management portfolio through a new strategic collaboration agreement with CSPC Pharmaceuticals to advance the development of multiple next-generation therapies for obesity and type 2 diabetes across eight programmes.

Scope of the GLP-1 RAs & Incretin-based Therapies Pipeline Report

• Coverage: Global
• Key GLP-1 RAs & Incretin-based Therapies Companies: egeneron, Hansoh Pharma, Pfizer, Eli Lily and Company, Roche, Boehringer Ingelheim, vTv Therapeutics, Neurocrine Biosciences, MetaVia, Sciwind Biosciences, Kailera Therapeutics, Viking Therapeutics, Structure Therapeutics, D and D Pharmatech, Huadong Medicine, SCOHIA PHARMA, Vivani Medical, Biolexis Therapeutics, Regor Therapeutics, RenaissThera, Immunoforge, Corxel Pharmaceuticals, 4Moving Biotech, Zealand Pharma, Ascletis, United Laboratories International, Landmark Medicines, and others.
• Key Pipeline GLP-1 RAs & Incretin-based Therapies Therapies: Olatorepatide, PF-08653944, Retatrutide, CT-388, BI 3034701, TTP273, NBIP-'1968, DA-1726, XW014, HRS9531, VK 2735, Aleniglipron, MET-875o, MET-GGGi, SCO-094, NPM-115, BLX-7006, RGT-075, RT-1000, RT-2000, RT-4000, Froniglutide, CX11, 4P 004, Dapiglutide, ASC 35, UBT 48128, Research program: GLP-1 receptor agonists, and others.

New Oral GLP-1

Table of Contents

1.	GLP-1 RAs & Incretin-based Therapies Pipeline Report Introduction
2.	GLP-1 RAs & Incretin-based Therapies Pipeline Report Executive Summary
3.	GLP-1 RAs & Incretin-based Therapies Pipeline: Overview
4.	GLP-1 RAs & Incretin-based Therapies Marketed Drugs
4.1.	MOUNJARO: Eli Lilly and Company
5.	GLP-1 RAs & Incretin-based Therapies Clinical Trial Therapeutics
6.	GLP-1 RAs & Incretin-based Therapies Pipeline: Late-Stage Products (Pre-registration)
7.	GLP-1 RAs & Incretin-based Therapies Pipeline: Late-Stage Products (Phase III)
7.1.	PF-08653944: Pfizer
8.	GLP-1 RAs & Incretin-based Therapies Pipeline: Mid-Stage Products (Phase II)
8.1.	TTP273: vTv Therapeutics
9.	GLP-1 RAs & Incretin-based Therapies Pipeline: Early-Stage Products (Phase I)
9.1.	NBIP-'1968: Neurocrine Biosciences
10.	GLP-1 RAs & Incretin-based Therapies Pipeline: Preclinical and Discovery Stage Products
11.	GLP-1 RAs & Incretin-based Therapies Pipeline Therapeutics Assessment
12.	Inactive Products in the GLP-1 RAs & Incretin-based Therapies Pipeline
13.	Company-University Collaborations (Licensing/Partnering) Analysis
14.	Unmet Needs
15.	GLP-1 RAs & Incretin-based Therapies Market Drivers and Barriers
16.	Appendix

For further information on GLP-1 agonists oral effectiveness, reach out @ Next Generation GLP-1 Drugs

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