Deltamethrin Impairs Fish Immunity Through The Brain-Thyroid-Immune Axis

(MENAFN- EIN Presswire)

HOW DELTAMETHRIN DISRUPTS THE GUT–BRAIN–THYROID AXIS AND WEAKENS FISH IMMUNITY, AND HOW DIETARY SODIUM BUTYRATE ALLEVIATES THESE EFFECTS.

GA, UNITED STATES, October 21, 2026 /EINPresswire / -- Deltamethrin disrupts gut bacteria and brain clock signaling, impairing antibacterial immunity in Nile tilapia through the brain–thyroid–immune axis. Dietary sodium butyrate alleviates this immune damage.

Deltamethrin is used in agriculture and public health and can enter waterways through runoff. Its effects on fish are often assessed through tissue damage or death. A new study(doi: ) in Environmental Chemistry and Ecotoxicology examined another concern: whether prolonged exposure undermines the immune cells that help fish fight infection. Fish receiving dietary sodium butyrate showed improved immune-cell proliferation and bacterial engulfment, reduced intestinal inflammation and lower liver bacterial loads. Thyroid-related gene expression also partially recovered. The results provide an experimental basis for exploring nutritional approaches to reduce pesticide-related immune damage.

The team first exposed Nile tilapia to deltamethrin and tested their response to the bacterial pathogen Streptococcus agalactiae. After 28 days of exposure at 1 microgram per liter, myeloid cells, frontline defenders that engulf bacteria, responded less effectively to infection. The fish also carried higher bacterial loads in their livers.

“Exposure changed the gut bacterial community, reducing Cetobacterium and increasing Leucobacter,” says corresponding author Ye Chen, from. Zhejiang University.“To test whether these changes contributed to immune damage, we transferred gut bacteria from exposed donors into recipient fish. The recipients developed similar defects in immune-cell function and bacterial clearance.”

Further, brain analyses revealed reduced expression of clocka, a core biological-clock gene.“Blocking Clock function with the compound CLK8 also weakened antibacterial defenses and reduced thyroid-related hormone signals,” says Chen.“These experiments support a connection between gut microbial imbalance, brain clock signaling and immune function.”

“Our findings suggest that pesticide-related immune damage involves communication between organs, extending beyond injury to individual tissues,” says first author Yi Cao.“This offers a new perspective on how prolonged exposure can affect resistance to infection.”

DOI

Original Source URL

Funding information
National Natural Science Foundation of China (Grant No. 32473191); Leading Goose R&D Program of Zhejiang (2024C03230).

Lucy Wang
BioDesign Research

Legal Disclaimer:

EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.

You just read:

Deltamethrin impairs fish immunity through the brain-thyroid-immune axis News Provided By BioDesign Research October 21, 2026, 11:45 GMT Share This Article Distribution channels: Environment, Science

EIN Presswire's priority is author transparency. We do our best to weed out false and misleading content. The content above is the sole responsibility of the author who makes it available. If you have any complaints, kindly contact the author above.

MENAFN21102026003118003196ID1111843578