CAR T-Cell Therapy For NHL Clinical Trial Landscape Expands: Over 70 Companies Advancing Next-Generation Therapies Delveinsight

A snapshot of the Pipeline CAR T-cell Therapy for NHL Drugs mentioned in the report:

Learn more about the CAR T-cell therapy for NHL research @ CAR T-cell Therapy for NHL Clinical Trials

Stuti Mahajan, consulting manager at DelveInsight, said that the NHL CAR-T market is entering a new wave of innovation, with a rapidly expanding pipeline seeking to overcome limitations of current CD19-directed therapies through dual-targeting, allogeneic, and in-vivo approaches. Growing clinical activity across earlier treatment lines and hard-to-treat relapsed/refractory populations is broadening the potential addressable patient pool, while continued trial initiations and regulatory milestones are sustaining competitive momentum.

Recent Developments in CAR T-cell Therapy for NHL Treatment Space

• In August 2026, AbelZeta Pharma, Inc. announced that the Company received the US Food and Drug Administration (FDA) clearance of IND application for C-CAR039, also known as Prizloncabtagene Autoleucel (Prizlon-cel), an anti-CD20/CD19 bispecific CAR-T, for the treatment of relapsed or refractory (r/r) Large B-cell Lymphoma (LBCL).
• In July 2026, Allogene Therapeutics, Inc. announced that the US Food and Drug Administration (FDA) has granted Regenerative Medicine Advanced Therapy (RMAT) and Fast Track designations to cemacabtagene ansegedleucel (cema-cel) for the treatment of adult patients with large B-cell lymphoma (LBCL) who, at the completion of first-line (1L) therapy, are in complete or partial response suitable for observation but test positive for minimal residual disease (MRD).
• In July 2026, Umoja Biopharma announced that the FDA has cleared its Investigational New Drug (IND) application for UB-VV400, a CD22-directed in vivo CAR T-cell therapy candidate for adults with relapsed or refractory B-cell malignancies.
• In June 2026, Caribou Biosciences, Inc. announced that vispa-cel, its off-the-shelf CD19-targeted CAR-T cell therapy, produced durable long-term responses in patients enrolled in the ANTLER Phase I clinical trial for relapsed or refractory B cell non-Hodgkin lymphoma (r/r B-NHL), with the potential to bring the benefit of cell therapy to patients who lack curative options.
• In June 2026, Lyell Immunopharma, Inc. announced new safety data from the ongoing Phase I/II clinical trial of rondecabtagene autoleucel (ronde-cel) in patients with relapsed or refractory (R/R) large B-cell lymphoma (LBCL) in the second-line (2L) and third- and later-line (3L+) settings and new translational data for ronde-cel.
• In June 2026, Legend Biotech Corporation reported the first clinical proof-of-concept results for LB2501, its investigational in vivo dual-targeting CD19/CD20 CAR-T cell therapy, in patients with relapsed or refractory B-cell non-Hodgkin lymphoma (R/R B-NHL). The findings are being showcased in a late-breaking presentation (Abstract #LB5006) at the 2026 European Hematology Association (EHA) Congress.
• In May 2026, CARsgen Therapeutics Holdings Limited announced that the Investigational New Drug (IND) application for CT1190B (an allogeneic CAR T-cell product targeting CD19/CD20) was accepted by the National Medical Products Administration (NMPA). The product is intended to be used for the conduct of a Phase Ib clinical trial in patients with relapsed/refractory large B-cell lymphoma (R/R LBCL) who have failed at least two lines of prior standard therapy.
• In May 2026, Miltenyi Biomedicine has submitted a Marketing Authorization Application to the European Medicines Agency (EMA) for zamtocabtagene autoleucel (zamto cel) for the treatment of adult patients with large B-cell lymphoma (LBCL), including diffuse large B-cell lymphoma (DLBCL), high grade B-cell lymphoma (HGBL), primary mediastinal large B-cell lymphoma (PMBCL) and transformations of indolent B-cell lymphomas who relapsed within 24 months from start of, or are refractory to, first-line chemoimmunotherapy.
• In March 2026, Leman Biotech Co., Ltd. announced that the US Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for META 10-19, a metabolically armored CD19-targeted CAR-T cell therapy. The IND clearance enables the initiation of US-based clinical studies for patients with relapsed or refractory (R/R) CD19-positive B-cell hematologic malignancies. Targeted indications include B-cell non-Hodgkin lymphoma (B-NHL), such as diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and mantle cell lymphoma (MCL).
• In February 2026, Lyell Immunopharma, Inc. announced that the first patient has been dosed in the PiNACLE – H2H Phase III trial evaluating rondecabtagene autoleucel (ronde-cel, also known as LYL314) compared to lisocabtagene maraleucel (liso-cel) or axicabtagene ciloleucel (axi-cel) for the treatment of patients with relapsed or refractory (R/R) large B-cell lymphoma (LBCL) receiving treatment in the second-line (2L) setting.

Scope of the CAR T-cell Therapy for NHL Pipeline Report

• Coverage: Global
• CAR T-cell Therapy for NHL Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination
• CAR T-cell Therapy for NHL Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
• CAR T-cell Therapy for NHL Therapeutics Assessment By Route of Administration: Oral, Intravenous, Subcutaneous, Parenteral, Topical
• Key CAR T-cell Therapy for NHL Companies: Lyell Immunopharma, Inc., Kure Cells, Inc., Allogene Therapeutics, Elicera Therapeutics, Caribou Biosciences, CARsgen Therapeutics, Marker Therapeutics, Inc., Orcar Bio, Imugene Limited, Cellectis, Luminary Therapeutics, Allotera Therapeutics, Prescient Therapeutics, March Biosciences, Legend Biotech, Miltenyi Biomedicine, Imviva Biotech, AvenCell Therapeutics, Umoja Biopharma, AbelZeta Pharma, Inc., Leman Biotech Co., Ltd. and others.
• Key CAR T-cell Therapies for NHL in Pipeline: Rondecabtagene autoleucel, UF-KURE19, Cemacabtagene Ansegedleucel, ELC-301, Vispa-cel, CT1190B, MT-601, Research Program: NHL, Azer-cel, Eti-cel, LMY-920, Sofi-cel, PTX-100, MB-105, MB-107, LB2501, LB2302, Zamto­cabta­gene autoleucel, CTD402, AVC-203, UB-VV400/410, UB-VV300/310, Prizloncabtagene Autoleucel, META 10-19 and others.

CAR T-cell Therapy for NHL News

Table of Contents

1.	CAR T-cell Therapy for NHL Pipeline Report Introduction
2.	CAR T-cell Therapy for NHL Pipeline Report Executive Summary
3.	CAR T-cell Therapy for NHL Pipeline: Overview
4.	Analytical Perspective In-depth Commercial Assessment
5.	CAR T-cell Therapy for NHL Clinical Trial Therapeutics
6.	CAR T-cell Therapy for NHL Pipeline: Late-Stage Products (Pre-registration)
7.	CAR T-cell Therapy for NHL Pipeline: Late-Stage Products (Phase III)
8.	CAR T-cell Therapy for NHL Pipeline: Mid-Stage Products (Phase II)
9.	CAR T-cell Therapy for NHL Pipeline: Early-Stage Products (Phase I)
10.	CAR T-cell Therapy for NHL Pipeline Therapeutics Assessment
11.	Inactive Products in the CAR T-cell Therapy for NHL Pipeline
12.	Company-University Collaborations (Licensing/Partnering) Analysis
13.	Key Companies
14.	Key Products in the CAR T-cell Therapy for NHL Pipeline
15.	Unmet Needs
16.	Market Drivers and Barriers
17.	Future Perspectives and Conclusion
18.	Analyst Views
19.	Appendix

For further information on the CAR T-cell therapy for NHL clinical trials, reach out @ CAR T-cell Therapy for NHL Medication

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