Onco-Innovations (CBOE CA: ONCO) (OTCQB: ONNVF) Enters LOI For Exclusive Option On LAG-3 Inhibitor Program

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Onco-Innovations (CBOE CA: ONCO) (OTCQB: ONNVF) (Frankfurt: W1H) (WKN: A3EKSZ) entered into a non-binding letter of intent (“LOI”) with Ifowonco Informatics Incorporated as an initial step toward negotiating a definitive agreement that, if completed, would grant Onco an exclusive option relating to Ifowonco's proprietary small-molecule inhibitor program targeting lymphocyte-activation gene 3 (“LAG-3”). The proposed collaboration is intended to combine Ifowonco's oral small-molecule immune checkpoint technology with Onco-Innovations' expertise in DNA damage response (“DDR”) therapeutics, translational oncology and clinical development, with the companies believing the combination of DDR inhibition and LAG-3 blockade could potentially enhance anti-tumour immune responses across multiple solid tumour indications.

Ifowonco's program is focused on developing orally available small-molecule LAG-3 inhibitors, in contrast with currently approved LAG-3 therapies administered intravenously as monoclonal antibodies. The companies intend to evaluate the LAG-3 program independently and, where supported by preclinical findings, explore its potential use alongside DDR-based therapeutic approaches, including Onco-Innovations' ONC010 program. CEO Thomas O'Shaughnessy said the potential agreement could position the company“at the intersection of precision oncology and next-generation cancer immunotherapy.”

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About Onco-Innovations Limited

Onco-Innovations is a Canadian-based company dedicated to cancer research and treatment, specializing in oncology. Onco's mission is to pursue the prevention and treatment of cancer through pioneering research and innovative solutions. The Company has secured an exclusive worldwide license to patented technology that targets solid tumours.

NOTE TO INVESTORS: The latest news and updates relating to ONNVF are available in the company's newsroom at

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