Chloe James

(MENAFN- The Conversation)

• Professor of Microbiology, University of Salford

Profile Articles

My primary research centers around temperate bacteriophages and how their carriage alters the biology of their bacterial hosts. I also lead projects investigating virulent phages, host-pathogen interactions and antimicrobial resistance (AMR).
I am passionate about the open sharing of scientific research through public engagement and outreach. I work across disciplines and with creative practitioners to develop immersive and engaging installations to improve public interest in microbiology.

Experience

• 2022–present Professor of Microbiology, University of Salford
• 2017–2022 Senior Lecturer in Medical Microbiology, University of Salford
• 2012–2017 Lecturer in Medical Microbiology, University of Salford
• 2009–2012 Postdoctoral Researcher, University of Liverpool
• 2006–2008 Postdoctoral Researcher - Marie Curie Funded, Universite Aix-Marseille
• 2003–2006 Postdoctoral Researcher - NIH Funded, University of Florida

Education

• 2003 The University of Liverpool, PhD Microbiology
• 1998 The University of Edinburgh, BSc. hons Medical Microbiology

Publications

• 2026 Exploring Phages Through Play: Creative 3D models for Science Engagement, Access Microbiology
• 2024 Antimicrobials: An update on new strategies to diversify treatment for bacterial infections, Advances in Microbial Physiology
• 2024 Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics, J. Vis. Exp. doi:10.3791/64945
• 2021 Comparative analysis of gene prediction tools for viral genome annotation, Biorxiv
• 2021 Antibiotic resistance profiles and population structure of disease-associated Staphylococcus aureus infecting patients in Fort Portal Regional Referral Hospital, Western Uganda, Microbiology
• 2018 Ram locus is a key regulator to trigger multidrug resistance in Enterobacter aerogenes, Journal of Medical Microbiology doi: 10.1099/jmm.0.000667
• 2017 C. jejuni transcriptome changes during loss of culturability in water, PLoSOne doi: 1371/journal.0188936
• 2017 Evolutionary diversification of P. aeruginosa in an artificial sputum model, BMC Microbiology DOI:10.1186/s12866-016-0916-z
• 2017 Fifty important research questions in microbial ecology, FEMS Microbiol Ecol
• 2016 The role of temperate bacteriophages in bacterial infection, FEMS Microbiology Letters doi10.1093/femsle/fnw015
• 2016 Temperate phages enhance pathogen fitness in chronic lung infection, ISME J
• 2016 Temperate phages both mediate and drive adaptive evolution in pathogen biofilms, PNAS
• 2015 Lytic activity by temperate phages of Pseudomonas aeruginosa in long-term cystic fibrosis chronic lung infections, The ISME Journal. doi: 10.1038/ismej.2014.223
• 2015 Polylysogeny magnifies competitiveness of a bacterial pathogen in vivo, Evolutionary Applications DOI: 10.1111/eva.12243
• 2014 Recent Advances in Studies of Polymicrobial Interactions in Oral Biofilms, Curr Oral Health Rep
• 2014 Role of environmental survival in transmission of Campylobacter jejuni, FEMS Microbiol. Letts.
• 2012 Use of artificial sputum medium to test antibiotic efficacy against Pseudomonas aeruginosa in conditions more relevant to the cystic fibrosis lung, JoVE DOI: 10.3791/3857-v
• 2012 Novel therapeutic strategies to counter Pseudomonas aeruginosa infections, Expert Reviews of Anti Infective Therapy DOI: 10.1586/eri.11.168
• 2012 Differential infection properties of three inducible prophages from an epidemic strain of Pseudomonas aeruginosa, BMC Microbiology
• 2011 The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa, AAC
• 2010 HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms, Pharmacogenetics and Genomics doi: 10.1097/FPC.0b013e328335b02d
• 2009 How B-Lactam Antibiotics Enter Bacteria: A Dialogue with the Porins, PLoS One
• 2008 Membrane permeability and regulation of drug "influx and efflux" in enterobacterial pathogens, Curr Drug Targets
• 2008 The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria, Nat Rev Microbiol.
• 2007 An Early Response to Environmental Stress Involves Regulation of OmpX and OmpF, Two Enterobacterial Outer Membrane Pore Forming Proteins, AAC. DOI:10.1128/AAC.01481-06
• 2007 Intrinsic Apoptotic Pathways of Gingival Epithelial Cells Modulated by Porphyromonas gingivalis, Cell Microbiol.
• 2007 Short-tailed Stx Phages Exploit the Conserved YaeT Protein to Disseminate Shiga Toxin Genes Amongst Enterobacteria, J Bacteriol.
• 2006 A P. gingivalis Haloacid Dehalogenase Family Phosphatase Interacts with Human Phosphoproteins and is Important for Invasion, PNAS
• 2006 S. gordonii utilizes several distinct gene functions to recruit P. gingivalis into a mixed community, Mol. Microbiol. doi:10.1111/j.1365-2958.2006.05099.x
• 2006 Expression of the Short Fimbriae of Porphyromonas gingivalis is Regulated in Oral Bacterial Consortia, FEMS Microbiol. Lett.
• 2006 LuxS Involvement in the Regulation of Genes Coding for Hemin and Iron Acquisition Systems in Porphyromonas gingivalis, Infect. Immun. doi: 10.1128/IAI.01768-05
• 2005 Survival of shiga toxin-encoding bacteriophage in a compost model, FEMS Microbiol Letts. 1016/j.2005.03.031
• 2003 Immunity profiles of wild-type and recombinant verotoxin-encoding bacteriophages and characterization of novel double lysogens, Infect Immun. doi: 10.1128/IAI.71.6.3409-3418.2003
• 2001 Lytic and lysogenic infection of diverse Escherichia coli and Shigella strains by verotoxigenic bacteriophages, Appl Environ Microbiol. doi: 10.1128/AEM.67.9.4335-4337.2001
• 2001 Phage mediated transfer of virulence genes, J Chem Tech Biotech.

Grants and Contracts

• 2025 Relationship Building - Bridging the gap between basic laboratory studies and clinical trials in wound healing biotechnology Role: PI Funding Source: IBIC
• 2024 Immersive tools for active and creative engagement in STEM subjects Role: PI Funding Source: HEIF
• 2021 Antimicrobial Surface Coatings for Controlling Infection Transmission Role: Co-I Funding Source: HEIF
• 2020 Prophage host interactions: pulling back the curtains on Pseudomonas puppet masters Role: PI Funding Source: BBSRC BB/T016256/1

Professional Memberships

• The Microbiology Society
• Applied Microbiology International

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