Hormone Sensitive Advanced Prostate Cancer Research Report 2025-2035: PSA Screening, Genomic Profiling And Combination Therapies Drive Shift To Personalized Treatment

(MENAFN- GlobeNewsWire - Nasdaq) The global hormone sensitive advanced prostate cancer (HSPC) market is witnessing substantial growth due to rising prostate cancer cases, advancements in hormonal and combination treatments, and precision medicine. HSPC represents a prostate cancer stage that responds to hormone therapy, managed with androgen deprivation therapy (ADT) and next-generation androgen receptor inhibitors (ARIs). Market expansion stems from improved early detection through PSA screening, genomic profiling, and combination therapy endorsements. Challenges include adoption barriers for novel therapies and regional treatment disparities. The competitive landscape involves pharmaceutical leaders, biotech innovators, and academic collaborations driving therapeutic innovations.

Dublin, Sept. 30, 2025 (GLOBE NEWSWIRE) -- The "Hormone Sensitive Advanced Prostate Cancer Market - A Global and Regional Analysis: Focus on Drug Class, Treatment, and Region - Analysis and Forecast, 2025-2035" report has been added to ResearchAndMarkets's offering.
The global hormone sensitive advanced prostate cancer (HSPC) market is experiencing significant growth, driven by the rising incidence of prostate cancer, advances in hormonal and combination therapies, and an increasing emphasis on precision medicine. HSPC refers to a stage of prostate cancer where the disease still responds to hormone therapy and is often managed with androgen deprivation therapy (ADT) alone or in combination with next-generation androgen receptor inhibitors (ARIs) and chemotherapy. As treatment paradigms shift toward intensification strategies, the global market is expanding through collaborative efforts among healthcare providers, biopharmaceutical companies, and research institutions focused on improving survival outcomes and quality of life for patients.
Growth in the HSPC market is underpinned by improvements in early detection through prostate-specific antigen (PSA) screening, next-generation imaging, and expanded genomic profiling that enables earlier and more tailored interventions. These diagnostic advancements support the use of targeted treatments, including ARIs such as enzalutamide and apalutamide, in conjunction with ADT and, in select cases, chemotherapy. As clinical guidelines increasingly endorse combination regimens for both high and low-volume metastatic HSPC, the treatment landscape is evolving rapidly toward a more personalized approach. Moreover, the adoption of digital monitoring tools and telehealth platforms is enhancing patient management, adherence, and follow-up care further accelerating market momentum.
Currently, the therapeutic focus in HSPC lies in improving progression free survival and delaying the transition to castration-resistant prostate cancer (CRPC), which is more difficult to manage. Combination therapies have shown survival benefits in multiple large-scale trials and these findings are reshaping clinical practice globally. In addition to hormonal therapies, the pipeline includes PSMA-targeted radioligand therapies, PARP inhibitors for genetically defined subgroups, and immune oncology combinations all of which offer opportunities to expand treatment efficacy while addressing patient specific tumor biology. While surgery and radiation therapy continue to play roles in localized disease, systemic therapy dominates the treatment of advanced hormone sensitive cases, with growing emphasis on optimizing sequences and combinations of agents.
The increasing global burden of prostate cancer, particularly in aging male populations, coupled with growing healthcare infrastructure in emerging economies, presents strong opportunities for sustained market growth. Regional expansion is facilitated by improved screening programs, access to oral AR-targeted agents, and the broader availability of urologic and oncologic care. Advances in clinical genomics, real world data integration, and health economics are also enabling value-based care models that align innovation with long-term affordability. As patient advocacy groups and professional societies push for updated treatment standards and improved access, the HSPC market is poised to benefit from rising awareness and policy support for advanced prostate cancer management.
Despite its strong outlook, the HSPC market faces several challenges. These include therapeutic inertia in early adoption of combination regimens, regional disparities in diagnostic and treatment access, and the high cost of novel therapies, which may limit uptake in low- and middle-income countries. Furthermore, side effects associated with intensified treatments such as fatigue, cardiovascular events, and cognitive impairment pose concerns for both patients and providers, particularly in elderly populations. Regulatory hurdles, especially for new classes of agents such as radioligand therapies and novel immunotherapies, may also delay broader market entry.
The competitive landscape in the HSPC market is shaped by leading pharmaceutical players, biotech innovators, and academic consortia pursuing both incremental and breakthrough innovations. Strategic partnerships, licensing deals, and mergers are common as stakeholders look to extend product lifecycles, co-develop next-generation therapies, and expand geographic reach. Clinical development efforts are focused on triplet therapies, biomarker-driven subgroup trials, and optimized sequencing strategies to outpace resistance and delay disease progression. The robust pipeline and continuous publication of real-world evidence are expected to fuel further differentiation and therapeutic advances.
Looking ahead, the global HSPC market is projected to maintain steady growth, supported by increasing adoption of personalized treatment protocols, digital health integration, and advances in translational research. As healthcare systems shift toward proactive cancer management and survivorship models, the role of HSPC therapeutics will expand within the broader prostate cancer continuum. With a strong emphasis on early intervention, patient-centered care, and treatment innovation, the HSPC market is well-positioned to deliver improved outcomes and sustain growth across developed and emerging healthcare settings in the years to come.

The hormone sensitive advanced prostate cancer (HSPC) market will continue to evolve, with a strong focus on therapeutic intensification strategies, biomarker-driven treatment personalization, and the integration of novel androgen receptor inhibitors and radioligand therapies. Growing clinical consensus around combination regimens, coupled with expanding access to genomic profiling and next-generation imaging, will play a pivotal role in shaping the future trajectory of the HSPC market. As the market matures, the convergence of real-world evidence, improved patient adherence models, and supportive reimbursement frameworks will foster innovation and broader adoption. Ongoing research into emerging modalities including PSMA targeted therapies, PARP inhibitor combinations, and immune-hormonal synergies will further drive clinical differentiation, positioning HSPC therapeutics as a high-priority segment within the global oncology and urology treatment landscape.
Key Topics Covered:
Executive Summary
Scope and Definition
Market/Product Definition
Inclusion and Exclusion
Key Questions Answered
Analysis and Forecast Note
1. Global Hormone Sensitive Advanced Prostate Cancer Market: Industry Analysis
1.1 Market Overview and Ecosystem
1.2 Epidemiological Analysis
1.3 Key Market Trends
1.3.1 Impact Analysis
1.4 Regulatory Landscape
1.5 Pipeline Analysis
1.6 Market Dynamics
1.6.1 Overview
1.6.2 Market Drivers
1.6.3 Market Restraints
1.6.4 Market Opportunities
2. Global Hormone Sensitive Advanced Prostate Cancer Market (by Drug Class), Value ($million), 2023-2035
2.1 Androgen Receptor Inhibitors
2.2 Chemotherapy Drugs
2.3 Corticosteroid
2.4 Immunotherapies
2.5 Targeted Radiotherapies
3. Global Hormone Sensitive Advanced Prostate Cancer Market (by Treatment), Value ($million), 2023-2035
3.1 Oral
3.2 Intravenous
3.3 Subcutaneous
4. Global Hormone Sensitive Advanced Prostate Cancer Market (by Region), Value ($Million), 2023-2035
4.1 North America
4.1.1 Market Dynamics
4.1.2 Market Sizing and Forecast
4.1.3 North America Hormone Sensitive Advanced Prostate Cancer Market, by Country ($Million), 2023-2035
4.1.3.1 U.S.
4.1.3.2 Canada
4.2 Europe
4.2.1 Market Dynamics
4.2.2 Market Sizing and Forecast
4.2.3 Europe Hormone Sensitive Advanced Prostate Cancer Market, by Country ($Million), 2023-2035
4.2.3.1 U.K.
4.2.3.2 France
4.2.3.3 Germany
4.2.3.4 Italy
4.2.3.5 Spain
4.2.3.6 Rest-of-Europe
4.3 Asia-Pacific
4.3.1 Market Dynamics
4.3.2 Market Sizing and Forecast
4.3.3 Asia-Pacific Hormone Sensitive Advanced Prostate Cancer Market, by Country ($Million), 2023-2035
4.3.3.1 Japan
4.3.3.2 China
4.3.3.3 India
4.3.3.4 Australia
4.3.3.5 South Korea
4.3.3.6 Rest-of-Asia-Pacific
4.4 Rest-of-the-World
4.4.1 Market Dynamics
4.4.2 Market Sizing and Forecast
4.4.3 Rest-of-the-World Hormone Sensitive Advanced Prostate Cancer Market, by Country ($Million), 2023-2035
4.4.3.1 Latin America
4.4.3.2 Middle East and Africa
5. Competitive Landscape and Company Profiles
5.1 Competitive Landscape
5.1.1 Mergers and Acquisitions
5.1.2 Partnership, Alliances and Business Expansion
5.1.3 New Offerings
5.1.4 Regulatory Activities
5.1.5 Funding Activities
5.2 Company Profiles
5.2.1 Amgen Inc.
5.2.1.1 Overview
5.2.1.2 Top Products / Product Portfolio
5.2.1.3 Top Competitors
5.2.1.4 Target Customers/End-Users
5.2.1.5 Key Personnel
5.2.1.6 Analyst View
5.2.2 Astellas Pharma Inc.
5.2.3 Bayer AG
5.2.4 Bristol-Myers Squibb Company
5.2.5 Dendreon Pharmaceuticals LLC
5.2.6 GlaxoSmithKline plc (GSK)
5.2.7 Merck & Co., Inc.
5.2.8 Novartis AG
5.2.9 Pfizer Inc.
5.2.10 Teva Pharmaceutical Industries Ltd.
6. Research Methodology

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