Why Is Cyclic Adenosine Monophosphate (Camp) Called“Life's Second Messenger”?

Cyclic adenosine monophosphate - sometimes called adenosine monophosphate cyclic or cAMP cyclic adenosine monophosphate - is not a protein, but a powerful intracellular messenger molecule. Known as“life's second messenger”, it works inside cells to relay instructions from hormones and other“first messengers,” regulating everything from metabolism to immunity. What Does Cyclic Adenosine Monophosphate Do in the Body?

Once generated from ATP by the enzyme adenylyl cyclase, cAMP activates proteins such as protein kinase A (PKA) , setting off biochemical reactions that influence brain function, cardiovascular health, fat metabolism, and more.

Although cAMP exists in many organisms, one of the richest natural sources is the Chinese jujube (Ziziphus jujuba)**. Importantly, not every jujube variety can be used for high‐quality jujube extract - only Ziziphus jujuba grown in specific regions of China contains the exceptional cAMP levels needed for premium nutraceutical production. This is the foundation of JUJUBE cAMP , developed by Sinofn Health through its own farms, clinical trials, and advanced extraction process.

From Nobel Prize Discovery to Modern Nutrition Science

In 1965, American scientist Earl Wilbur Sutherland Jr. proposed the theory of the“second messenger,” and the crucial role of cyclic adenosine monophosphate gradually became widely recognized.

In 1971, Sutherland was awarded the Nobel Prize in Physiology or Medicine for discovering cAMP's function.

In 2000, Eric Richard Kandel of Columbia University received the Nobel Prize for discovering how cAMP influences brain function.

First Messengers vs. Second Messengers What Are First Messengers?

Chemical signals secreted by cells, including:

• Proteins and polypeptides (e.g., insulin, cytokines)

• Amino acids and derivatives (e.g., adrenaline, thyroxine)

• Steroid hormones (e.g., sex hormones, corticosteroids)

• Fatty acid derivatives (e.g., prostaglandins)

• Gases (e.g., nitric oxide, carbon monoxide)

What Are Second Messengers?

Small molecules that relay and amplify those external signals inside the cell. Examples include:

• cAMP (cyclic adenosine monophosphate)

• cGMP

• Calcium ions (Ca2+)

• Inositol phosphates

• Nitric oxide (NO)

Sutherland discovered that adrenaline alone could not trigger the breakdown of glycogen in the liver - cAMP was required to complete the process.

How cAMP Works at the Cellular Level

cAMP indirectly alters protein activity by activating protein kinases like PKA, which phosphorylate target proteins in metabolic pathways. Without cAMP, many hormones and signaling molecules cannot fully function inside cells.

Natural Sources of cAMP

For years, extracting cAMP in useful quantities was difficult. That changed when Japanese researchers found that Ziziphus jujuba grown in China contained thousands of times more cAMP than most foods - making large‐scale extraction feasible.

Note for buyers: Many“jujube” species globally have negligible cAMP levels. To ensure potency and quality, manufacturers must use Ziziphus jujuba from verified, high‐cAMP regions - exactly what Sinofn Health cultivates.

Biological Functions of cAMP Supports Brain Function

• Enhances memory

• Repairs neurons

• Reduces fatigue

Improves Sleep and Memory

• Supports healthy brain metabolism

• Promotes neuron renewal

Regulates Immunity

• Modulates antibody production

• Balances immune cell activity

Anti‐Tumor Potential

• Promotes apoptosis in abnormal cells

• Inhibits proliferation

Enhances Hematopoiesis

• Stimulates bone marrow to produce blood cells

Cardiovascular Benefits

• Strengthens heart function

• Reduces oxidative damage

Liver Protection

• Prevents fatty liver

• Supports recovery in liver disease

Allergy Relief

• Reduces inflammation in allergic conditions

Skin Health & Anti‐Aging

• Promotes circulation

• Prevents pigmentation

• Slows visible aging

Endocrine Regulation

• Helps restore hormonal balance disrupted by age or illness

Why Sinofn Health Leads in cAMP Nutraceuticals

• Own jujube farms in high‐cAMP regions of China

• In‐house extraction and purification technology

• Clinical trials confirming efficacy

• OEM/ODM supplement manufacturing for global brands

Next Steps Explore to see how Sinofn Health leads in high‐cAMP jujube cultivation, research, and OEM nutraceutical production.

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