The missile struck the medical facility in the Razeh district of Saada province according to communications officer Malak Shaher.

She said MSF could not specify whether the centre was hit in an airstrike by the Saudi-led coalition or by a rocket fired from the ground.

Saada is the heartland of the Iran-backed Shiite Houthi rebels that the coalition has been bombing since March in support of Yemen's beleaguered government.

MSF last month accused the coalition of bombing its clinic in Taez southwest Yemen where nine persons were wounded including two agency staff.

The coalition said at the time that it would investigate MSF's claim.

The UN envoy for Yemen Ismail Ould Cheikh Ahmed arrived on Sunday in Sanaa in a bid to convince the rebels and their allies to attend fresh peace talks slated for next week.

But Foreign Minister Abdel Malak al Mekhlafi said on Saturday that the talks will not take place until January 20 at the earliest. The government met the rebels and their allies in Switzerland last month for six days of talks that ended with no major breakthrough.

In Yemen's second city of Aden on Sunday intelligence colonel Ali Saleh al Nakhibi was shot dead by unknown gunmen a security official said.

More than 5800 people have been killed in Yemen since March about half of them civilians according to the United Nations.